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Literature DB >> 20177825

Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation.

Abstract

Pax6 regulates formation of cerebral cortex, axon guidance, differentiation of neurons from glia and neuronal migration in the cerebellum. Although Pax6 is known to be a nuclear protein, it is presumed that it may interact with matricelluar proteins like SPARC during transport and processing of Pax6. The proteins involved in cell survival and cell proliferation can also not be ignored. The present study demonstrates co-localization of Pax6, secreted protein acidic rich in cysteine (SPARC), and p53 in astrocytes of primary culture, cerebellum and cortex region of mouse brain. The physical interaction of Pax6 with SPARC and p53 in brain of mice is also evident. The Pax6 probably participates with p53 to regulate neuronal survival. It indicates that the interaction of Pax6, SPARC and p53 may influence Smad3-dependent auto-regulation of Pax6.

Entities: Chemical Gene Species

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Year: 2010 PMID： 20177825 DOI： 10.1007/s12031-010-9334-0

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

29 in total

1. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.

Authors: A Francki; A D Bradshaw; J A Bassuk; C C Howe; W G Couser; E H Sage
Journal: J Biol Chem Date: 1999-11-05 Impact factor: 5.157

2. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

Authors: R S Morrison; H J Wenzel; Y Kinoshita; C A Robbins; L A Donehower; P A Schwartzkroin
Journal: J Neurosci Date: 1996-02-15 Impact factor: 6.167

Review 3. The biology of SPARC, a protein that modulates cell-matrix interactions.

Authors: T F Lane; E H Sage
Journal: FASEB J Date: 1994-02 Impact factor: 5.191

4. Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain.

Authors: D B Mendis; I R Brown
Journal: Brain Res Mol Brain Res Date: 1994-07

5. A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.

Authors: Monika S Brill; Marina Snapyan; Hilde Wohlfrom; Jovica Ninkovic; Melanie Jawerka; Grant S Mastick; Ruth Ashery-Padan; Armen Saghatelyan; Benedikt Berninger; Magdalena Götz
Journal: J Neurosci Date: 2008-06-18 Impact factor: 6.167

6. The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.

Authors: J E Schwarzbauer; C S Spencer
Journal: Mol Biol Cell Date: 1993-09 Impact factor: 4.138

7. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects.

Authors: T Glaser; L Jepeal; J G Edwards; S R Young; J Favor; R L Maas
Journal: Nat Genet Date: 1994-08 Impact factor: 38.330

Review 8. Pax6 3' deletion results in aniridia, autism and mental retardation.

Authors: L K Davis; K J Meyer; D S Rudd; A L Librant; E A Epping; V C Sheffield; T H Wassink
Journal: Hum Genet Date: 2008-03-06 Impact factor: 4.132

9. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.

Authors: Simon T Cooper; Isabel M Hanson
Journal: BMC Genet Date: 2005-08-12 Impact factor: 2.797

10. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

Authors: S Estus; W J Zaks; R S Freeman; M Gruda; R Bravo; E M Johnson
Journal: J Cell Biol Date: 1994-12 Impact factor: 10.539

8 in total

Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation.

1. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.

2. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

Review 3. The biology of SPARC, a protein that modulates cell-matrix interactions.

4. Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain.

5. A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.

6. The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.

7. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects.

Review 8. Pax6 3' deletion results in aniridia, autism and mental retardation.

9. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.

10. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1. Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice.

2. Autoregulation of Pax6 in neuronal cells is mediated by Pax6(5a), Pax6(ΔPD), SPARC, and p53.

3. Pax6 interacts with SPARC and TGF-β in murine eyes.

4. ELISA based quantification of Pax6 expression in the developing Zebrafish embryos.

Review 5. Regulation of Apoptosis During Porcine Circovirus Type 2 Infection.

6. Pax6 influences expression patterns of genes involved in neuro- degeneration.

Review 7. The genetic architecture of aniridia and Gillespie syndrome.

8. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression.