Literature DB >> 20177800

Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages.

Kazunori Inaba1, Kazuya Murata, Shunsuke Naruto, Hideaki Matsuda.   

Abstract

Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of inflammatory cytokines [interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] in mouse macrophage cells (RAW 264.7). Harpagoside, a major iridoid glycoside present in devil's claw, was found to be one of the active agents in HP-ext and inhibited the production of IL-1beta, IL-6, and TNF-alpha by RAW 264.7.

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Year:  2010        PMID： 20177800     DOI： 10.1007/s11418-010-0395-8

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  9 in total

1.  Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.

Authors:  Tom Hsun-Wei Huang; Van H Tran; Rujee K Duke; Sharon Tan; Sigrun Chrubasik; Basil D Roufogalis; Colin C Duke
Journal:  J Ethnopharmacol       Date:  2005-10-03       Impact factor: 4.360

2.  An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri.

Authors:  B Baghdikian; M C Lanhers; J Fleurentin; E Ollivier; C Maillard; G Balansard; F Mortier
Journal:  Planta Med       Date:  1997-04       Impact factor: 3.352

3.  Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease.

Authors:  L W Whitehouse; M Znamirowska; C J Paul
Journal:  Can Med Assoc J       Date:  1983-08-01       Impact factor: 8.262

4.  Accelerated granuloma formation in adjuvant-induced arthritic rats and its modification by antirheumatic drugs.

Authors:  H Nakamura; M Shimizu
Journal:  J Pharmacol Exp Ther       Date:  1979-10       Impact factor: 4.030

5.  Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis.

Authors:  Z Szekanecz; M M Halloran; M V Volin; J M Woods; R M Strieter; G Kenneth Haines; S L Kunkel; M D Burdick; A E Koch
Journal:  Arthritis Rheum       Date:  2000-06

6.  Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens.

Authors:  M C Lanhers; J Fleurentin; F Mortier; A Vinche; C Younos
Journal:  Planta Med       Date:  1992-04       Impact factor: 3.352

7.  Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats.

Authors:  Monica L Andersen; Eduardo H R Santos; Maria de Lourdes V Seabra; Ana A B da Silva; Sergio Tufik
Journal:  J Ethnopharmacol       Date:  2004-04       Impact factor: 4.360

8.  Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929.

Authors:  Mi-Hyeon Jang; Sabina Lim; Seung-Moo Han; Hi-Joon Park; Insop Shin; Jin-Woo Kim; Nam-Jae Kim; Ji-Suk Lee; Kyung-Ah Kim; Chang-Ju Kim
Journal:  J Pharmacol Sci       Date:  2003-11       Impact factor: 3.337

9.  Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis.

Authors:  Koji Takasugi; Masahiro Yamamura; Mitsuhiro Iwahashi; Fumio Otsuka; Jiro Yamana; Katsue Sunahori; Masanori Kawashima; Masao Yamada; Hirofumi Makino
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156
  9 in total
  9 in total

1.  Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes.

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2.  Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

Authors:  Abdul Haseeb; Mohammad Yunus Ansari; Tariq M Haqqi
Journal:  J Orthop Res       Date:  2016-05-04       Impact factor: 3.494

Review 3.  The analgesic potential of glycosides derived from medicinal plants.

Authors:  Haroon Khan; Aini Pervaiz; Sebastiano Intagliata; Niranjan Das; Kalyan C Nagulapalli Venkata; Atanas G Atanasov; Agnieszka Najda; Seyed Mohammad Nabavi; Dongdong Wang; Valeria Pittalà; Anupam Bishayee
Journal:  Daru       Date:  2020-02-14       Impact factor: 3.117

4.  Antimutagenic potential of harpagoside and Harpagophytum procumbens against 1-nitropyrene.

Authors:  Luigi Manon; Baghdikian Béatrice; Orsière Thierry; Pompili Jocelyne; Mabrouki Fathi; Ollivier Evelyne; Botta Alain
Journal:  Pharmacogn Mag       Date:  2015-05       Impact factor: 1.085

5.  Effects of JSOG-6 on protection against bone loss in ovariectomized mice through regulation of osteoblast differentiation and osteoclast formation.

Authors:  Hwa-Jin Chung; Lan Cho; Joon-Shik Shin; Jinho Lee; In-Hyuk Ha; Hyen Joo Park; Sang Kook Lee
Journal:  BMC Complement Altern Med       Date:  2014-06-06       Impact factor: 3.659

6.  The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages.

Authors:  Hwa-Jin Chung; Wonil Koh; Won Kyung Kim; Joon-Shik Shin; Jinho Lee; Sang Kook Lee; In-Hyuk Ha
Journal:  Mediators Inflamm       Date:  2018-04-05       Impact factor: 4.711

7.  Effects of a nutritional supplement in dogs affected by osteoarthritis.

Authors:  Nadia Musco; Giuseppe Vassalotti; Vincenzo Mastellone; Laura Cortese; Giorgia Della Rocca; Maria Luce Molinari; Serena Calabrò; Raffaella Tudisco; Monica Isabella Cutrignelli; Pietro Lombardi
Journal:  Vet Med Sci       Date:  2019-07-17

8.  Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial.

Authors:  Marcela González-Gross; Carlos Quesada-González; Javier Rueda; Manuel Sillero-Quintana; Nicolas Issaly; Angel Enrique Díaz; Eva Gesteiro; David Escobar-Toledo; Rafael Torres-Peralta; Marc Roller; Amelia Guadalupe-Grau
Journal:  Int J Environ Res Public Health       Date:  2021-05-22       Impact factor: 3.390

9.  Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects.

Authors:  Hong Liu; Yan-fang Zheng; Chu-yuan Li; Yu-ying Zheng; De-qin Wang; Zhong Wu; Lin Huang; Yong-gang Wang; Pei-bo Li; Wei Peng; Wei-wei Su
Journal:  Sci Rep       Date:  2015-12-10       Impact factor: 4.996
  9 in total

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