Literature DB >> 17981007

Analyses of Titanocenes in the spheroid-based cellular angiogenesis assay.

Holger Weber1, James Claffey, Megan Hogan, Clara Pampillón, Matthias Tacke.   

Abstract

Titanocene dichloride and two of its derivatives (Titanocene Y and C) were tested on human umbilical vein endothelial cells (HUVEC) sprouting in a spheroid-based cellular angiogenesis assay in order to determine IC50 values of inhibition. Titanocene dichloride and Titanocene Y inhibited HUVEC sprouting in this angiogenesis assay with IC50 values of 19 microM and 4.9 microM, while Titanocene C surprisingly showed no inhibition. This classifies Titanocene dichloride as a purely anti-angiogenic anticancer drug and Titanocene C as a purely cytotoxic anticancer drug. On the other hand, Titanocene Y combines both favourable anticancer activities and seems to be the drug candidate of choice for further optimisation.

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Year:  2007        PMID： 17981007     DOI： 10.1016/j.tiv.2007.09.014

Source DB:  PubMed          Journal:  Toxicol In Vitro        ISSN： 0887-2333            Impact factor:   3.500


  8 in total

1.  Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.

Authors:  Li Ming Gao; Jaime Matta; Arnold L Rheingold; Enrique Meléndez
Journal:  J Organomet Chem       Date:  2009-12-15       Impact factor: 2.369

2.  Titanium(IV) complexes: cytotoxicity and cellular uptake of titanium(IV) complexes on caco-2 cell line.

Authors:  Ramón Hernández; Janet Méndez; José Lamboy; Madeline Torres; Féliz R Román; Enrique Meléndez
Journal:  Toxicol In Vitro       Date:  2009-09-20       Impact factor: 3.500

3.  Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7.

Authors:  Li Ming Gao; Enrique Meléndez
Journal:  Met Based Drugs       Date:  2010-05-04

4.  Water-soluble molybdenocene complexes with both proliferative and antiproliferative effects on cancer cell lines and their binding interactions with human serum albumin.

Authors:  Idainés Feliciano; Jaime Matta; Enrique Meléndez
Journal:  J Biol Inorg Chem       Date:  2009-06-18       Impact factor: 3.358

5.  A proposed mechanism for the inhibitory effect of the anticancer agent titanocene dichloride on tumour gelatinases and other proteolytic enzymes.

Authors:  Maria Pavlaki; Katerina Debeli; Irene-Eva Triantaphyllidou; Nikolaos Klouras; Eleftheria Giannopoulou; Alexios J Aletras
Journal:  J Biol Inorg Chem       Date:  2009-04-24       Impact factor: 3.358

Review 6.  Organometallic anticancer compounds.

Authors:  Gilles Gasser; Ingo Ott; Nils Metzler-Nolte
Journal:  J Med Chem       Date:  2010-11-15       Impact factor: 7.446

7.  Cell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour.

Authors:  Silvia Blacher; Charlotte Erpicum; Bénédicte Lenoir; Jenny Paupert; Gustavo Moraes; Sandra Ormenese; Eric Bullinger; Agnès Noel
Journal:  PLoS One       Date:  2014-05-07       Impact factor: 3.240

8.  An advanced glioma cell invasion assay based on organotypic brain slice cultures.

Authors:  Tanja Eisemann; Barbara Costa; Jens Strelau; Michel Mittelbronn; Peter Angel; Heike Peterziel
Journal:  BMC Cancer       Date:  2018-01-30       Impact factor: 4.430
  8 in total

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