BACKGROUND: The extent to which adequate nutrition from infant diets differentially influence developmental outcomes in healthy infants has not been determined. AIM: To compare the effects of the major infant diets on the development of brain electrical activity during infancy. STUDY DESIGN: Scalp EEG signals (124 sites) recorded from the same infants during quiet wakefulness at 3, 6, 9, and 12months. SUBJECTS: Healthy, full-term infants (40/group; gender matched) either breastfed (BF) or fed milk formula (MF) or soy formula (SF) through the first 6months. OUTCOME MEASURES: Power spectral values for frequencies in the 0.1-30Hz range. RESULTS: Significant diet-related differences were present across frequency bands and included effects that were time- [peaks in 0.1-3Hz at 6 (MF,SF) and 9months (BF); 3-6Hz at 6months (MF, SF>BF); increases in 6-9Hz from 3 to 6months (MF>BF) and from 6 to 9months (MF>SF)] and gender-related (9-12Hz and 12-30Hz: at 9months BF>MF, SF boys, and MF>SF girls). CONCLUSIONS: The development of brain electrical activity during infancy differs between those who are breastfed compared with those fed either milk or soy formula, but is generally similar for formula-fed groups. These variations in EEG activity reflect diet-related influences on the development of brain structure and function that could put infants on different neurodevelopmental trajectories along which cognitive and brain function development will proceed.
BACKGROUND: The extent to which adequate nutrition from infant diets differentially influence developmental outcomes in healthy infants has not been determined. AIM: To compare the effects of the major infant diets on the development of brain electrical activity during infancy. STUDY DESIGN: Scalp EEG signals (124 sites) recorded from the same infants during quiet wakefulness at 3, 6, 9, and 12months. SUBJECTS: Healthy, full-term infants (40/group; gender matched) either breastfed (BF) or fed milk formula (MF) or soy formula (SF) through the first 6months. OUTCOME MEASURES: Power spectral values for frequencies in the 0.1-30Hz range. RESULTS: Significant diet-related differences were present across frequency bands and included effects that were time- [peaks in 0.1-3Hz at 6 (MF,SF) and 9months (BF); 3-6Hz at 6months (MF, SF>BF); increases in 6-9Hz from 3 to 6months (MF>BF) and from 6 to 9months (MF>SF)] and gender-related (9-12Hz and 12-30Hz: at 9months BF>MF, SF boys, and MF>SF girls). CONCLUSIONS: The development of brain electrical activity during infancy differs between those who are breastfed compared with those fed either milk or soy formula, but is generally similar for formula-fed groups. These variations in EEG activity reflect diet-related influences on the development of brain structure and function that could put infants on different neurodevelopmental trajectories along which cognitive and brain function development will proceed.
Authors: Sarah U Morton; Brian J Leyshon; Eleonora Tamilia; Rutvi Vyas; Michaela Sisitsky; Imran Ladha; John B Lasekan; Matthew J Kuchan; P Ellen Grant; Yangming Ou Journal: Front Psychiatry Date: 2022-06-23 Impact factor: 5.435
Authors: Margaret C Neville; Steven M Anderson; James L McManaman; Thomas M Badger; Maya Bunik; Nikhat Contractor; Tessa Crume; Dana Dabelea; Sharon M Donovan; Nicole Forman; Daniel N Frank; Jacob E Friedman; J Bruce German; Armond Goldman; Darryl Hadsell; Michael Hambidge; Katie Hinde; Nelson D Horseman; Russell C Hovey; Edward Janoff; Nancy F Krebs; Carlito B Lebrilla; Danielle G Lemay; Paul S MacLean; Paula Meier; Ardythe L Morrow; Josef Neu; Laurie A Nommsen-Rivers; Daniel J Raiten; Monique Rijnkels; Victoria Seewaldt; Barry D Shur; Joshua VanHouten; Peter Williamson Journal: J Mammary Gland Biol Neoplasia Date: 2012-07-01 Impact factor: 2.673