BACKGROUND: Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders. METHODS: To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography to measure in vivo 5-HT(1A)R density and apparent dissociation constant (K(D)(app)) in the brain of juvenile Rhesus monkeys exposed to the early-life stress of peer-rearing. RESULTS: In general, 5-HT(1A)R density and K(D)(app) were decreased in peer-reared compared with control mother-reared animals. However, increase in receptor density was found in the dorsomedial prefrontal cortex of peer-reared females. CONCLUSIONS: These findings suggest that exposure to an adverse early-life environment during infancy is associated with long-term alterations in the serotonin system and support previous studies suggesting that reduced 5-HT(1A)R density during development might be a factor increasing vulnerability to stress-related neuropsychiatric disorders. Furthermore, alterations in the serotonin system seemed to be gender- and region-specific, providing a biological basis for the higher prevalence of affective disorders in women.
BACKGROUND:Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders. METHODS: To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography to measure in vivo 5-HT(1A)R density and apparent dissociation constant (K(D)(app)) in the brain of juvenile Rhesus monkeys exposed to the early-life stress of peer-rearing. RESULTS: In general, 5-HT(1A)R density and K(D)(app) were decreased in peer-reared compared with control mother-reared animals. However, increase in receptor density was found in the dorsomedial prefrontal cortex of peer-reared females. CONCLUSIONS: These findings suggest that exposure to an adverse early-life environment during infancy is associated with long-term alterations in the serotonin system and support previous studies suggesting that reduced 5-HT(1A)R density during development might be a factor increasing vulnerability to stress-related neuropsychiatric disorders. Furthermore, alterations in the serotonin system seemed to be gender- and region-specific, providing a biological basis for the higher prevalence of affective disorders in women.
Authors: Robert B Innis; Vincent J Cunningham; Jacques Delforge; Masahiro Fujita; Albert Gjedde; Roger N Gunn; James Holden; Sylvain Houle; Sung-Cheng Huang; Masanori Ichise; Hidehiro Iida; Hiroshi Ito; Yuichi Kimura; Robert A Koeppe; Gitte M Knudsen; Juhani Knuuti; Adriaan A Lammertsma; Marc Laruelle; Jean Logan; Ralph Paul Maguire; Mark A Mintun; Evan D Morris; Ramin Parsey; Julie C Price; Mark Slifstein; Vesna Sossi; Tetsuya Suhara; John R Votaw; Dean F Wong; Richard E Carson Journal: J Cereb Blood Flow Metab Date: 2007-05-09 Impact factor: 6.200
Authors: Jussi Hirvonen; Hasse Karlsson; Jaana Kajander; Antti Lepola; Juha Markkula; Helena Rasi-Hakala; Kjell Någren; Jouko K Salminen; Jarmo Hietala Journal: Int J Neuropsychopharmacol Date: 2007-10-31 Impact factor: 5.176
Authors: Wayne C Drevets; Michael E Thase; Eydie L Moses-Kolko; Julie Price; Ellen Frank; David J Kupfer; Chester Mathis Journal: Nucl Med Biol Date: 2007-10 Impact factor: 2.408
Authors: Eric E Nelson; Khalisa N Herman; Catherine E Barrett; Pamela L Noble; Kimberly Wojteczko; Kelli Chisholm; Deborah Delaney; Monique Ernst; Nathan A Fox; Stephen J Suomi; James T Winslow; Daniel S Pine Journal: Biol Psychiatry Date: 2009-05-17 Impact factor: 13.382
Authors: Audrey R Tyrka; Lauren Wier; Lawrence H Price; Nicole Ross; George M Anderson; Charles W Wilkinson; Linda L Carpenter Journal: Biol Psychiatry Date: 2008-03-12 Impact factor: 13.382
Authors: Jon R Nash; Peter A Sargent; Eugenii A Rabiner; Sean D Hood; Spilios V Argyropoulos; John P Potokar; Paul M Grasby; David J Nutt Journal: Br J Psychiatry Date: 2008-09 Impact factor: 9.319
Authors: Joana V Taylor Tavares; Luke Clark; Maura L Furey; Guy B Williams; Barbara J Sahakian; Wayne C Drevets Journal: Neuroimage Date: 2008-06-04 Impact factor: 6.556
Authors: Dustin W Wooten; Ansel T Hillmer; Jeffrey M Moirano; Elizabeth O Ahlers; Maxim Slesarev; Todd E Barnhart; Jogeshwar Mukherjee; Mary L Schneider; Bradley T Christian Journal: J Cereb Blood Flow Metab Date: 2012-04-04 Impact factor: 6.200
Authors: G M Alexander; J D Graef; J A Hammarback; B K Nordskog; E J Burnett; J B Daunais; A J Bennett; D P Friedman; S J Suomi; D W Godwin Journal: Neuroscience Date: 2012-01-21 Impact factor: 3.590
Authors: Doty J Kempf; Kate C Baker; Margaret H Gilbert; James L Blanchard; Reginald L Dean; Daniel R Deaver; Rudolf P Bohm Journal: Comp Med Date: 2012-06 Impact factor: 0.982
Authors: Dustin W Wooten; Ansel T Hillmer; Jeffrey M Moirano; Dana L Tudorascu; Elizabeth O Ahlers; Maxim S Slesarev; Todd E Barnhart; Jogeshwar Mukherjee; Mary L Schneider; Bradley T Christian Journal: Neuroimage Date: 2013-03-26 Impact factor: 6.556
Authors: Stephen G Lindell; Qiaoping Yuan; Zhifeng Zhou; David Goldman; Robert C Thompson; Juan F Lopez; Stephen J Suomi; J Dee Higley; Christina S Barr Journal: Dev Psychopathol Date: 2012-11
Authors: M Embree; V Michopoulos; J R Votaw; R J Voll; J Mun; J S Stehouwer; M M Goodman; M E Wilson; M M Sánchez Journal: Neuroscience Date: 2012-10-16 Impact factor: 3.590