BACKGROUND: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. OBJECTIVE: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. DESIGN, SETTING, AND PARTICIPANTS: The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial. MEASUREMENTS: The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers. RESULTS AND LIMITATIONS: The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men <65 yr of age with three affected brothers (HR: approximately 23) and the lowest for men between 65 and 74 yr of age with an affected father (HR: approximately 1.8). The HRs increased with decreasing paternal or fraternal diagnostic age. The pattern of the risk of death from familial PCa was similar to the incidence data. CONCLUSIONS: The present results should guide clinical counselling and demonstrate the vast increases in risk when multiple first-degree relatives are affected. Copyright (c) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
BACKGROUND: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. OBJECTIVE: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. DESIGN, SETTING, AND PARTICIPANTS: The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial. MEASUREMENTS: The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers. RESULTS AND LIMITATIONS: The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men <65 yr of age with three affected brothers (HR: approximately 23) and the lowest for men between 65 and 74 yr of age with an affected father (HR: approximately 1.8). The HRs increased with decreasing paternal or fraternal diagnostic age. The pattern of the risk of death from familial PCa was similar to the incidence data. CONCLUSIONS: The present results should guide clinical counselling and demonstrate the vast increases in risk when multiple first-degree relatives are affected. Copyright (c) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Authors: Aubrey R Turner; Brian R Lane; Dan Rogers; Isaac Lipkus; Kathryn Weaver; Suzanne C Danhauer; Zheng Zhang; Fang-Chi Hsu; Sabrina L Noyes; Tamara Adams; Helga Toriello; Thomas Monroe; Trudy McKanna; Tracey Young; Ryan Rodarmer; Richard J Kahnoski; Mouafak Tourojman; A Karim Kader; S Lilly Zheng; William Baer; Jianfeng Xu Journal: Cancer Date: 2016-07-19 Impact factor: 6.860
Authors: Nathaniel Oswald; Tengda Lin; Benjamin Haaland; Michael Flynn; Kensaku Kawamoto; Kathleen A Cooney; William Lowrance; Heidi A Hanson; Brock O'Neil Journal: Cancer Epidemiol Date: 2020-05-08 Impact factor: 2.984
Authors: Marco Randazzo; Alexander Müller; Sigrid Carlsson; Daniel Eberli; Andreas Huber; Rainer Grobholz; Lukas Manka; Ashkan Mortezavi; Tullio Sulser; Franz Recker; Maciej Kwiatkowski Journal: BJU Int Date: 2015-10-06 Impact factor: 5.588