BACKGROUND: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. METHODS: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer >/= 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. RESULTS: The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 +/- 10.6 years and 52.0 +/- 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0%vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8%vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925). CONCLUSION: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first. Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
BACKGROUND: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. METHODS: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer >/= 1:40) of antibodies to H1N1influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. RESULTS: The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 +/- 10.6 years and 52.0 +/- 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1influenza virus of the hospital staff was significantly higher than that of the control group (20.0%vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1influenza virus of group 1 were significantly higher than that of group 2 (30.8%vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925). CONCLUSION: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first. Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
Authors: Michael E Greenberg; Michael H Lai; Gunter F Hartel; Christine H Wichems; Charmaine Gittleson; Jillian Bennet; Gail Dawson; Wilson Hu; Connie Leggio; Diane Washington; Russell L Basser Journal: N Engl J Med Date: 2009-09-10 Impact factor: 91.245
Authors: Fatimah S Dawood; Seema Jain; Lyn Finelli; Michael W Shaw; Stephen Lindstrom; Rebecca J Garten; Larisa V Gubareva; Xiyan Xu; Carolyn B Bridges; Timothy M Uyeki Journal: N Engl J Med Date: 2009-05-07 Impact factor: 91.245
Authors: J C Gaydos; R A Hodder; F H Top; V J Soden; R G Allen; J D Bartley; J H Zabkar; T Nowosiwsky; P K Russell Journal: J Infect Dis Date: 1977-12 Impact factor: 5.226
Authors: Rebecca J Garten; C Todd Davis; Colin A Russell; Bo Shu; Stephen Lindstrom; Amanda Balish; Wendy M Sessions; Xiyan Xu; Eugene Skepner; Varough Deyde; Margaret Okomo-Adhiambo; Larisa Gubareva; John Barnes; Catherine B Smith; Shannon L Emery; Michael J Hillman; Pierre Rivailler; James Smagala; Miranda de Graaf; David F Burke; Ron A M Fouchier; Claudia Pappas; Celia M Alpuche-Aranda; Hugo López-Gatell; Hiram Olivera; Irma López; Christopher A Myers; Dennis Faix; Patrick J Blair; Cindy Yu; Kimberly M Keene; P David Dotson; David Boxrud; Anthony R Sambol; Syed H Abid; Kirsten St George; Tammy Bannerman; Amanda L Moore; David J Stringer; Patricia Blevins; Gail J Demmler-Harrison; Michele Ginsberg; Paula Kriner; Steve Waterman; Sandra Smole; Hugo F Guevara; Edward A Belongia; Patricia A Clark; Sara T Beatrice; Ruben Donis; Jacqueline Katz; Lyn Finelli; Carolyn B Bridges; Michael Shaw; Daniel B Jernigan; Timothy M Uyeki; Derek J Smith; Alexander I Klimov; Nancy J Cox Journal: Science Date: 2009-05-22 Impact factor: 47.728
Authors: Anna J X Zhang; Kelvin K W To; Herman Tse; Kwok-Hung Chan; Kun-Yuan Guo; Can Li; Ivan F N Hung; Jasper F W Chan; Honglin Chen; Sidney Tam; Kwok-Yung Yuen Journal: Clin Vaccine Immunol Date: 2011-09-07
Authors: Babasaheb V Tandale; Shailesh D Pawar; Yogesh K Gurav; Mandeep S Chadha; Santosh S Koratkar; Vijay N Shelke; Akhilesh C Mishra Journal: BMC Infect Dis Date: 2010-08-25 Impact factor: 3.090
Authors: David S Hui; Benny K Chow; Leo Chu; Susanna S Ng; Nelson Lee; Tony Gin; Matthew T V Chan Journal: PLoS One Date: 2012-12-05 Impact factor: 3.240