Literature DB >> 20171099

Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.

Colin K Skepper1, Doralyn S Dalisay, Tadeusz F Molinski.   

Abstract

Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20171099      PMCID： PMC2834865          DOI： 10.1016/j.bmcl.2010.01.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

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  1 in total

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