Literature DB >> 20169412

What is life? Defining life in the context of emergent complexity.

Bruce H Weber1.   

Abstract

Erwin Schrödinger defined life not only as a "self-reproducing" aperiodic crystal of DNA coding for proteins but within the context of living entities increasing their order by dissipating matter/energy gradients to maintain themselves away from equilibirium. Since then most definitions of life have focused on the former. But living cells do more than replicate their DNA. Cells also have membrane barriers across which metabolites must move, via which energy transduction as well as information processing occurs, and within which metabolic transformation occurs. An approach of complex systems dynamics, including nonequilibrium thermodynamics, may provide a more robust approach for defining life than a "naked replicator" at the origin of life. The crucial issue becomes the process of emergence of life from pre-biotic chemistry, concomitant with the emergence of function, information, and semiosis. Living entities can be viewed as bounded, informed autocatalytic cycles feeding off matter/energy gradients, exhibiting agency, capable of growth, reproduction, and evolution. Understanding how life might have emerged should sharpen our definition of what life is.

Mesh:

Year:  2010        PMID: 20169412     DOI: 10.1007/s11084-010-9203-4

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN: 0169-6149            Impact factor:   1.950


  27 in total

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3.  Optimal combinations of imperfect objects.

Authors:  Damien Challet; Neil F Johnson
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4.  Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

5.  Implications of thermodynamics of protein folding for evolution of primary sequences.

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6.  Origins of life: How leaky were primitive cells?

Authors:  David W Deamer
Journal:  Nature       Date:  2008-07-03       Impact factor: 49.962

7.  The origin of life and its methodological challenge.

Authors:  G Wächtershäuser
Journal:  J Theor Biol       Date:  1997-08-21       Impact factor: 2.691

8.  Carbonyl sulfide-mediated prebiotic formation of peptides.

Authors:  Luke Leman; Leslie Orgel; M Reza Ghadiri
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9.  Template-directed synthesis of a genetic polymer in a model protocell.

Authors:  Sheref S Mansy; Jason P Schrum; Mathangi Krishnamurthy; Sylvia Tobé; Douglas A Treco; Jack W Szostak
Journal:  Nature       Date:  2008-06-04       Impact factor: 49.962

Review 10.  The concept of self-organization in cellular architecture.

Authors:  T Misteli
Journal:  J Cell Biol       Date:  2001-10-15       Impact factor: 10.539

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  4 in total

Review 1.  Systems protobiology: origin of life in lipid catalytic networks.

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Journal:  J R Soc Interface       Date:  2018-07       Impact factor: 4.118

2.  Origin of evolution versus origin of life: a shift of paradigm.

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Journal:  Int J Mol Sci       Date:  2011-06-01       Impact factor: 5.923

3.  The major transitions of life from a network perspective.

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Journal:  Front Physiol       Date:  2012-04-10       Impact factor: 4.566

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