Literature DB >> 12593777

The first cell membranes.

David Deamer1, Jason P Dworkin, Scott A Sandford, Max P Bernstein, Louis J Allamandola.   

Abstract

Organic compounds are synthesized in the interstellar medium and can be delivered to planetary surfaces such as the early Earth, where they mix with endogenous species. Some of these compounds are amphiphilic, having polar and nonpolar groups on the same molecule. Amphiphilic compounds spontaneously self-assemble into more complex structures such as bimolecular layers, which in turn form closed membranous vesicles. The first forms of cellular life required self-assembled membranes that were likely to have been produced from amphiphilic compounds on the prebiotic Earth. Laboratory simulations show that such vesicles readily encapsulate functional macromolecules, including nucleic acids and polymerases. The goal of future investigations will be to fabricate artificial cells as models of the origin of life.

Mesh:

Year:  2002        PMID: 12593777     DOI: 10.1089/153110702762470482

Source DB:  PubMed          Journal:  Astrobiology        ISSN: 1557-8070            Impact factor:   4.335


  54 in total

1.  Historical development of origins research.

Authors:  Antonio Lazcano
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-06-09       Impact factor: 10.005

2.  Visualization of membrane RNAs.

Authors:  Tadeusz Janas; Michael Yarus
Journal:  RNA       Date:  2003-11       Impact factor: 4.942

3.  Inversion concept of the origin of life.

Authors:  V N Kompanichenko
Journal:  Orig Life Evol Biosph       Date:  2012-05-29       Impact factor: 1.950

Review 4.  Toward understanding protocell mechanosensation.

Authors:  Daniel Balleza
Journal:  Orig Life Evol Biosph       Date:  2010-11-17       Impact factor: 1.950

5.  Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.

Authors:  Mario Ruiz; Rakesh Bodhicharla; Emma Svensk; Ranjan Devkota; Kiran Busayavalasa; Henrik Palmgren; Marcus Ståhlman; Jan Boren; Marc Pilon
Journal:  Elife       Date:  2018-12-04       Impact factor: 8.140

6.  Surfactant assemblies and their various possible roles for the origin(s) of life.

Authors:  Peter Walde
Journal:  Orig Life Evol Biosph       Date:  2006-04-27       Impact factor: 1.950

7.  Hydrothermal reactions of pyruvic acid: synthesis, selection, and self-assembly of amphiphilic molecules.

Authors:  Robert M Hazen; David W Deamer
Journal:  Orig Life Evol Biosph       Date:  2006-11-29       Impact factor: 1.950

8.  Prebiotic materials from on and off the early Earth.

Authors:  Max Bernstein
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-10-29       Impact factor: 6.237

9.  Steps towards the formation of a protocell: the possible role of short peptides.

Authors:  Maya Fishkis
Journal:  Orig Life Evol Biosph       Date:  2007-09-14       Impact factor: 1.950

10.  A membrane transporter for tryptophan composed of RNA.

Authors:  Teresa Janas; Tadeusz Janas; Michael Yarus
Journal:  RNA       Date:  2004-10       Impact factor: 4.942

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