Literature DB >> 20167806

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

Mathieu Laplante1, David M Sabatini.   

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Year:  2010        PMID： 20167806      PMCID： PMC2840435          DOI： 10.1073/pnas.1000323107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  21 in total

Review 1.  mTOR signaling at a glance.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  J Cell Sci       Date:  2009-10-15       Impact factor: 5.285

2.  Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

Authors:  Leila Khamzina; Alain Veilleux; Sébastien Bergeron; André Marette
Journal:  Endocrinology       Date:  2004-12-16       Impact factor: 4.736

3.  Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.

Authors:  Shijie Li; Michael S Brown; Joseph L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-01       Impact factor: 11.205

4.  The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

Authors:  Nicholas F Brown; Maja Stefanovic-Racic; Ian J Sipula; German Perdomo
Journal:  Metabolism       Date:  2007-11       Impact factor: 8.694

5.  The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.

Authors:  Tao Peng; Todd R Golub; David M Sabatini
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

6.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Authors:  Christopher B Newgard; Jie An; James R Bain; Michael J Muehlbauer; Robert D Stevens; Lillian F Lien; Andrea M Haqq; Svati H Shah; Michelle Arlotto; Cris A Slentz; James Rochon; Dianne Gallup; Olga Ilkayeva; Brett R Wenner; William S Yancy; Howard Eisenson; Gerald Musante; Richard S Surwit; David S Millington; Mark D Butler; Laura P Svetkey
Journal:  Cell Metab       Date:  2009-04       Impact factor: 27.287

Review 7.  The FoxO code.

Authors:  D R Calnan; A Brunet
Journal:  Oncogene       Date:  2008-04-07       Impact factor: 9.867

Review 8.  Selective versus total insulin resistance: a pathogenic paradox.

Authors:  Michael S Brown; Joseph L Goldstein
Journal:  Cell Metab       Date:  2008-02       Impact factor: 27.287

Review 9.  SREBP-1c transcription factor and lipid homeostasis: clinical perspective.

Authors:  P Ferré; F Foufelle
Journal:  Horm Res       Date:  2007-03-05

10.  SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

Authors:  Thomas Porstmann; Claudio R Santos; Beatrice Griffiths; Megan Cully; Mary Wu; Sally Leevers; John R Griffiths; Yuen-Li Chung; Almut Schulze
Journal:  Cell Metab       Date:  2008-09       Impact factor: 27.287
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  51 in total

1.  Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K.

Authors:  Z Cheng; S Surichan; K Ruparelia; R Arroo; M R Boarder
Journal:  Br J Pharmacol       Date:  2011-04       Impact factor: 8.739

2.  High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.

Authors:  Ryan T Birse; Joan Choi; Kathryn Reardon; Jessica Rodriguez; Suzanne Graham; Soda Diop; Karen Ocorr; Rolf Bodmer; Sean Oldham
Journal:  Cell Metab       Date:  2010-11-03       Impact factor: 27.287

3.  PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling.

Authors:  Gha Young Lee; Hagoon Jang; Jae Ho Lee; Jin Young Huh; Sekyu Choi; Jongkyeong Chung; Jae Bum Kim
Journal:  Mol Cell Biol       Date:  2013-12-30       Impact factor: 4.272

Review 4.  Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update.

Authors:  Kembra Albracht-Schulte; Nishan Sudheera Kalupahana; Latha Ramalingam; Shu Wang; Shaikh Mizanoor Rahman; Jacalyn Robert-McComb; Naima Moustaid-Moussa
Journal:  J Nutr Biochem       Date:  2018-02-27       Impact factor: 6.048

5.  mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.

Authors:  Ghada A Soliman; Hugo A Acosta-Jaquez; Diane C Fingar
Journal:  Lipids       Date:  2010-11-02       Impact factor: 1.880

Review 6.  Mechanisms of Insulin Action and Insulin Resistance.

Authors:  Max C Petersen; Gerald I Shulman
Journal:  Physiol Rev       Date:  2018-10-01       Impact factor: 37.312

Review 7.  Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.

Authors:  Sung Hee Choi; Henry N Ginsberg
Journal:  Trends Endocrinol Metab       Date:  2011-05-26       Impact factor: 12.015

Review 8.  Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective.

Authors:  Roger H F Wong; Hei Sook Sul
Journal:  Curr Opin Pharmacol       Date:  2010-12       Impact factor: 5.547

9.  Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Authors:  Paul M Titchenell; William J Quinn; Mingjian Lu; Qingwei Chu; Wenyun Lu; Changhong Li; Helen Chen; Bobby R Monks; Julia Chen; Joshua D Rabinowitz; Morris J Birnbaum
Journal:  Cell Metab       Date:  2016-05-26       Impact factor: 27.287

Review 10.  Translational approaches: from fatty liver to non-alcoholic steatohepatitis.

Authors:  Natalia Rosso; Norberto C Chavez-Tapia; Claudio Tiribelli; Stefano Bellentani
Journal:  World J Gastroenterol       Date:  2014-07-21       Impact factor: 5.742
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