Literature DB >> 20166889

The applied biochemistry of PEDF and implications for tissue homeostasis.

Matthew L Broadhead1, S Patricia Becerra, Peter F M Choong, Crispin R Dass.   

Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

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Year:  2010        PMID： 20166889      PMCID： PMC3931573          DOI： 10.3109/08977191003604513

Source DB:  PubMed          Journal:  Growth Factors        ISSN： 0897-7194            Impact factor:   2.511


  53 in total

1.  Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling.

Authors:  Pranab K Mukherjee; Victor L Marcheselli; Sebastian Barreiro; Jane Hu; Dean Bok; Nicolas G Bazan
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-01       Impact factor: 11.205

2.  Heparin binding induces a conformational change in pigment epithelium-derived factor.

Authors:  Zuzana Valnickova; Steen V Petersen; Søren B Nielsen; Daniel E Otzen; Jan J Enghild
Journal:  J Biol Chem       Date:  2007-01-02       Impact factor: 5.157

3.  Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells.

Authors:  Lydia W T Cheung; Simon C L Au; Annie N Y Cheung; Hextan Y S Ngan; Joyce Tombran-Tink; Nelly Auersperg; Alice S T Wong
Journal:  Endocrinology       Date:  2006-06-15       Impact factor: 4.736

Review 4.  PEDF: a potential molecular therapeutic target with multiple anti-cancer activities.

Authors:  Eugene T H Ek; Crispin R Dass; Peter F M Choong
Journal:  Trends Mol Med       Date:  2006-09-07       Impact factor: 11.951

5.  Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.

Authors:  Luigi Notari; Victoriano Baladron; J Daniel Aroca-Aguilar; Natalia Balko; Raul Heredia; Christina Meyer; Patricia M Notario; Senthil Saravanamuthu; Maria-Luisa Nueda; Francisco Sanchez-Sanchez; Julio Escribano; Jorge Laborda; S Patricia Becerra
Journal:  J Biol Chem       Date:  2006-10-10       Impact factor: 5.157

Review 6.  Anti-angiogenic therapy for osteosarcoma.

Authors:  Gerald M Y Quan; Peter F M Choong
Journal:  Cancer Metastasis Rev       Date:  2006-12       Impact factor: 9.264

7.  Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2.

Authors:  Ming Guan; Haowen Jiang; Chong Xu; Rong Xu; Zhongqing Chen; Yuan Lu
Journal:  Cancer Biol Ther       Date:  2007-03-28       Impact factor: 4.742

8.  Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis.

Authors:  E T H Ek; C R Dass; K G Contreras; P F M Choong
Journal:  Cancer Gene Ther       Date:  2007-05-04       Impact factor: 5.987

9.  Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).

Authors:  Dimitri T Azar
Journal:  Trans Am Ophthalmol Soc       Date:  2006

10.  Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor.

Authors:  Eugene T H Ek; Crispin R Dass; Karla G Contreras; Peter F M Choong
Journal:  Clin Exp Metastasis       Date:  2007-04-18       Impact factor: 5.150
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  13 in total

1.  Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses.

Authors:  Chandrakala S Jadhao; Ashay D Bhatwadekar; Youde Jiang; Michael E Boulton; Jena J Steinle; Maria B Grant
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-04-18       Impact factor: 4.799

2.  Pigment epithelium-derived factor as a multifunctional regulator of wound healing.

Authors:  Mateusz S Wietecha; Mateusz J Król; Elizabeth R Michalczyk; Lin Chen; Peter G Gettins; Luisa A DiPietro
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-07-10       Impact factor: 4.733

3.  Production and function of pigment epithelium-derived factor in isolated skin keratinocytes.

Authors:  Lin Chen; Luisa A DiPietro
Journal:  Exp Dermatol       Date:  2014-06       Impact factor: 3.960

4.  Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells.

Authors:  Manyun Xie; Jingyi Tian; Yan Luo; Liqing Wei; Shaofen Lin; Shibo Tang
Journal:  Mol Vis       Date:  2014-09-27       Impact factor: 2.367

5.  Electroconvulsive therapy modulates plasma pigment epithelium-derived factor in depression: a proteomics study.

Authors:  K M Ryan; A Glaviano; S M O'Donovan; E Kolshus; R Dunne; A Kavanagh; A Jelovac; M Noone; G M Tucker; M J Dunn; D M McLoughlin
Journal:  Transl Psychiatry       Date:  2017-03-28       Impact factor: 6.222

6.  TRIP-1 Promotes the Assembly of an ECM That Contains Extracellular Vesicles and Factors That Modulate Angiogenesis.

Authors:  Yinghua Chen; Anne George
Journal:  Front Physiol       Date:  2018-08-15       Impact factor: 4.566

Review 7.  Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy.

Authors:  María Liliana Franco-Chuaire; Sandra Ramírez-Clavijo; Lilian Chuaire-Noack
Journal:  Iran J Basic Med Sci       Date:  2015-09       Impact factor: 2.699

Review 8.  Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril.

Authors:  Cody L Hoop; Jie Zhu; Ana Monica Nunes; David A Case; Jean Baum
Journal:  Biomolecules       Date:  2017-11-01

Review 9.  Diabetes and Wound Angiogenesis.

Authors:  Uzoagu A Okonkwo; Luisa A DiPietro
Journal:  Int J Mol Sci       Date:  2017-07-03       Impact factor: 5.923

10.  Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo.

Authors:  Chi-Hsien Peng; Jen-Hua Chuang; Mong-Lien Wang; Yong-Yu Jhan; Ke-Hung Chien; Yu-Chien Chung; Kuo-Hsuan Hung; Chia-Ching Chang; Chao-Kuei Lee; Wei-Lien Tseng; De-Kuang Hwang; Chia-Hsien Hsu; Tai-Chi Lin; Shih-Hwa Chiou; Shih-Jen Chen
Journal:  Oncotarget       Date:  2016-10-04
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