Literature DB >> 16962374

PEDF: a potential molecular therapeutic target with multiple anti-cancer activities.

Eugene T H Ek1, Crispin R Dass, Peter F M Choong.   

Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities. Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor. We also discuss the prospects for PEDF therapy and the need for a closer evaluation of issues such as delivery, stability and potential toxicity.

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Year:  2006        PMID： 16962374     DOI： 10.1016/j.molmed.2006.08.009

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  48 in total

1.  Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity.

Authors:  Monika Deshpande; Luigi Notari; Preeti Subramanian; Vicente Notario; S Patricia Becerra
Journal:  Int J Oncol       Date:  2012-04-10       Impact factor: 5.650

2.  Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor.

Authors:  K W Leung; L W T Cheung; Y L Pon; R N S Wong; N K Mak; T-P D Fan; S C L Au; J Tombran-Tink; A S T Wong
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739

3.  Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.

Authors:  Masayoshi Arai; Asami Hayashi; Mari Sobou; Shunsuke Ishida; Takashi Kawachi; Naoyuki Kotoku; Motomasa Kobayashi
Journal:  J Nat Med       Date:  2010-11-02       Impact factor: 2.343

4.  PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.

Authors:  Jiho Sohn; Vimal Selvaraj; Kouji Wakayama; Lori Orosco; Eunyoung Lee; Susan E Crawford; Fuzheng Guo; Jordan Lang; Makoto Horiuchi; Konstantinos Zarbalis; Takayuki Itoh; Wenbin Deng; David Pleasure
Journal:  J Neurosci       Date:  2012-08-29       Impact factor: 6.167

5.  Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest.

Authors:  Alexander Konson; Sunila Pradeep; Cosimo Walter D'Acunto; Rony Seger
Journal:  J Biol Chem       Date:  2010-11-08       Impact factor: 5.157

6.  Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor.

Authors:  Geneviève Doyon; Stéphanie St-Jean; Mathieu Darsigny; Claude Asselin; Francois Boudreau
Journal:  J Biol Chem       Date:  2009-07-16       Impact factor: 5.157

Review 7.  The yin and yang of VEGF and PEDF: multifaceted neurotrophic factors and their potential in the treatment of Parkinson's Disease.

Authors:  Torsten Falk; Robert T Gonzalez; Scott J Sherman
Journal:  Int J Mol Sci       Date:  2010-08-05       Impact factor: 5.923

8.  Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.

Authors:  Takumi Kawaguchi; Sho-Ichi Yamagishi; Minoru Itou; Koji Okuda; Shuji Sumie; Ryoko Kuromatsu; Masahiro Sakata; Mitsuhiko Abe; Eitaro Taniguchi; Hironori Koga; Masaru Harada; Takato Ueno; Michio Sata
Journal:  Am J Pathol       Date:  2009-11-30       Impact factor: 4.307

9.  'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'.

Authors:  J L Orgaz; O Ladhani; K S Hoek; A Fernández-Barral; D Mihic; O Aguilera; E A Seftor; A Bernad; J L Rodríguez-Peralto; M J C Hendrix; O V Volpert; B Jiménez
Journal:  Oncogene       Date:  2009-09-21       Impact factor: 9.867

10.  The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts.

Authors:  Kathrin Rychli; Christoph Kaun; Philipp J Hohensinner; Adrian J Dorfner; Stefan Pfaffenberger; Alexander Niessner; Michael Bauer; Wolfgang Dietl; Bruno K Podesser; Gerald Maurer; Kurt Huber; Johann Wojta
Journal:  J Cell Mol Med       Date:  2010-01       Impact factor: 5.310
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