BACKGROUND: Androgens and growth factors are thought to be associated with prostate cancer risk, although past research has produced mixed results. METHODS: We conducted a nested case-control study of biomarkers of prostate cancer risk within the Multiethnic Cohort. We compared prediagnostic levels of testosterone, dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), 3alpha-androstanediol glucuronide (3alpha-diol G), insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein 1 (IGFBP-1), and IGFBP-3 in serum from 467 incident prostate cancer cases and 934 cancer-free controls. Controls were matched to the cases on geographic site (HI, LA), ethnicity, age at specimen collection (+/-1 year), date (+/-1 month) and time of day (+/-2 hr) of sample collection, and fasting status (<6, 6-7, 8-9, >10 hr). Multivariate conditional logistic regression models were used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Serum concentrations of testosterone, DHT, SHBG, 3alpha-diol G, IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were not associated with risk of prostate cancer. Tests for trend of quartiles of serum concentrations also did not show any association. Results were relatively unchanged for men with advanced prostate cancer and their matched controls. However, the follow-up period was relatively short (mean of 1.9 years). Analysis by ethnic group showed an increased risk for Latino men in the second (OR = 3.67, 95% CI: 1.63-8.24) and third (OR = 2.96, 95% CI: 1.19-7.40) tertiles of IGF-I serum levels compared with the first tertile. CONCLUSIONS: The suggested increased risk for IGF-I in Latino men merits further study, with greater statistical power.
BACKGROUND: Androgens and growth factors are thought to be associated with prostate cancer risk, although past research has produced mixed results. METHODS: We conducted a nested case-control study of biomarkers of prostate cancer risk within the Multiethnic Cohort. We compared prediagnostic levels of testosterone, dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), 3alpha-androstanediol glucuronide (3alpha-diol G), insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein 1 (IGFBP-1), and IGFBP-3 in serum from 467 incident prostate cancer cases and 934 cancer-free controls. Controls were matched to the cases on geographic site (HI, LA), ethnicity, age at specimen collection (+/-1 year), date (+/-1 month) and time of day (+/-2 hr) of sample collection, and fasting status (<6, 6-7, 8-9, >10 hr). Multivariate conditional logistic regression models were used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Serum concentrations of testosterone, DHT, SHBG, 3alpha-diol G, IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were not associated with risk of prostate cancer. Tests for trend of quartiles of serum concentrations also did not show any association. Results were relatively unchanged for men with advanced prostate cancer and their matched controls. However, the follow-up period was relatively short (mean of 1.9 years). Analysis by ethnic group showed an increased risk for Latino men in the second (OR = 3.67, 95% CI: 1.63-8.24) and third (OR = 2.96, 95% CI: 1.19-7.40) tertiles of IGF-I serum levels compared with the first tertile. CONCLUSIONS: The suggested increased risk for IGF-I in Latino men merits further study, with greater statistical power.
Authors: J V Lacey; A W Hsing; C M Fillmore; S Hoffman; K J Helzlsouer; G W Comstock Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-10 Impact factor: 4.254
Authors: Anand P Chokkalingam; Yu-Tang Gao; Jie Deng; Frank Z Stanczyk; Isabell A Sesterhenn; F K Mostofi; Joseph F Fraumeni; Ann W Hsing Journal: Prostate Date: 2002-07-01 Impact factor: 4.104
Authors: Chiaojung J Tsai; Barbara A Cohn; Piera M Cirillo; David Feldman; Frank Z Stanczyk; Alice S Whittemore Journal: Cancer Causes Control Date: 2006-12 Impact factor: 2.506
Authors: L N Kolonel; B E Henderson; J H Hankin; A M Nomura; L R Wilkens; M C Pike; D O Stram; K R Monroe; M E Earle; F S Nagamine Journal: Am J Epidemiol Date: 2000-02-15 Impact factor: 4.897
Authors: June M Chan; Meir J Stampfer; Jing Ma; Peter Gann; J Michael Gaziano; Michael Pollak; Edward Giovannucci Journal: J Natl Cancer Inst Date: 2002-07-17 Impact factor: 13.506
Authors: Karen Woodson; Joseph A Tangrea; Michael Pollak; Terry D Copeland; Philip R Taylor; Jarmo Virtamo; Demetrius Albanes Journal: Cancer Res Date: 2003-07-15 Impact factor: 12.701
Authors: Chu Chen; Noel S Weiss; Frank Z Stanczyk; S Kay Lewis; Dante DiTommaso; Ruth Etzioni; Matt J Barnett; Gary E Goodman Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-12 Impact factor: 4.254
Authors: Pär Stattin; Sonja Lumme; Leena Tenkanen; Henrik Alfthan; Egil Jellum; Göran Hallmans; Steinar Thoresen; Timo Hakulinen; Tapio Luostarinen; Matti Lehtinen; Joakim Dillner; Ulf-Håkan Stenman; Matti Hakama Journal: Int J Cancer Date: 2004-01-20 Impact factor: 7.396
Authors: Douglas K Price; Cindy H Chau; Cathee Till; Phyllis J Goodman; Robin J Leach; Teresa L Johnson-Pais; Ann W Hsing; Ashraful Hoque; Howard L Parnes; Jeannette M Schenk; Catherine M Tangen; Ian M Thompson; Juergen K V Reichardt; William D Figg Journal: Cancer Date: 2016-05-10 Impact factor: 6.860
Authors: Yin Cao; Katharina Nimptsch; Irene M Shui; Elizabeth A Platz; Kana Wu; Michael N Pollak; Stacey A Kenfield; Meir J Stampfer; Edward L Giovannucci Journal: Int J Cancer Date: 2014-11-10 Impact factor: 7.396
Authors: Ada Lee; Katya Rubinow; Richard V Clark; Ralph B Caricofe; Mark A Bush; Hui Zhi; Mara Y Roth; Stephanie T Page; William J Bremner; John K Amory Journal: J Androl Date: 2011-08-25
Authors: Konstantinos K Tsilidis; Ruth C Travis; Paul N Appleby; Naomi E Allen; Sara Lindström; Demetrius Albanes; Regina G Ziegler; Marjorie L McCullough; Afshan Siddiq; Aurelio Barricarte; Sonja I Berndt; H Bas Bueno-de-Mesquita; Stephen J Chanock; E David Crawford; W Ryan Diver; Susan M Gapstur; Edward Giovannucci; Fangyi Gu; Christopher A Haiman; Richard B Hayes; David J Hunter; Mattias Johansson; Rudolf Kaaks; Laurence N Kolonel; Peter Kraft; Loic Le Marchand; Kim Overvad; Silvia Polidoro; Elio Riboli; Fredrick R Schumacher; Victoria L Stevens; Dimitrios Trichopoulos; Jarmo Virtamo; Walter C Willett; Timothy J Key Journal: Int J Cancer Date: 2013-02-15 Impact factor: 7.396
Authors: Cindy Ke Zhou; Frank Z Stanczyk; Muhannad Hafi; Carmela C Veneroso; Barlow Lynch; Roni T Falk; Shelley Niwa; Eric Emanuel; Yu-Tang Gao; George P Hemstreet; Ladan Zolfghari; Peter R Carroll; Michael J Manyak; Isabell A Sesterhenn; Paul H Levine; Ann W Hsing; Michael B Cook Journal: Prostate Date: 2017-10-02 Impact factor: 4.104
Authors: Jeannette M Schenk; Cathee Till; Ann W Hsing; Frank Z Stanczyk; Zhihong Gong; Marian L Neuhouser; Juergen K Reichardt; Ashraful M Hoque; William D Figg; Phyllis J Goodman; Catherine M Tangen; Ian M Thompson Journal: Cancer Causes Control Date: 2015-11-20 Impact factor: 2.506