Literature DB >> 20165553

Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body.

Benjamin Shapiro1.   

Abstract

Magnetic drug delivery has the potential to target therapy to specific regions in the body, improving efficacy and reducing side effects for treatment of cancer, stroke, infection, and other diseases. Using stationary external magnets, which attract the magnetic drug carriers, this treatment is limited to shallow targets (<5 cm below skin depth using the strongest possible, still safe, practical magnetic fields). We consider dynamic magnetic actuation and present initial results that show it is possible to vary magnets one against the other to focus carriers between them on average. The many remaining tasks for deep targeting in-vivo are then briefly noted.

Entities:  

Year:  2009        PMID: 20165553      PMCID: PMC2822352          DOI: 10.1016/j.jmmm.2009.02.094

Source DB:  PubMed          Journal:  J Magn Magn Mater        ISSN: 0304-8853            Impact factor:   2.993


  7 in total

1.  Hydrodynamics of magnetic drug targeting.

Authors:  P A Voltairas; D I Fotiadis; L K Michalis
Journal:  J Biomech       Date:  2002-06       Impact factor: 2.712

2.  Active-edge planar radiation sensors.

Authors:  C J Kenney; J D Segal; E Westbrook; Sherwood Parker; J Hasi; C Da Via; S Watts; J Morse
Journal:  Nucl Instrum Methods Phys Res A       Date:  2006-09-01       Impact factor: 1.455

3.  Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach.

Authors:  Jean-Baptiste Mathieu; Sylvain Martel
Journal:  Biomed Microdevices       Date:  2007-12       Impact factor: 2.838

4.  Preclinical experiences with magnetic drug targeting: tolerance and efficacy.

Authors:  A S Lübbe; C Bergemann; W Huhnt; T Fricke; H Riess; J W Brock; D Huhn
Journal:  Cancer Res       Date:  1996-10-15       Impact factor: 12.701

5.  Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.

Authors:  A S Lübbe; C Bergemann; H Riess; F Schriever; P Reichardt; K Possinger; M Matthias; B Dörken; F Herrmann; R Gürtler; P Hohenberger; N Haas; R Sohr; B Sander; A J Lemke; D Ohlendorf; W Huhnt; D Huhn
Journal:  Cancer Res       Date:  1996-10-15       Impact factor: 12.701

6.  Magnetizable needles and wires--modeling an efficient way to target magnetic microspheres in vivo.

Authors:  Gh Iacob; O Rotariu; N J C Strachan; U O Häfeli
Journal:  Biorheology       Date:  2004       Impact factor: 1.875

7.  MRI after magnetic drug targeting in patients with advanced solid malignant tumors.

Authors:  A-J Lemke; M-I Senfft von Pilsach; A Lübbe; C Bergemann; H Riess; R Felix
Journal:  Eur Radiol       Date:  2004-08-05       Impact factor: 5.315

  7 in total
  17 in total

1.  The Behaviors of Ferro-Magnetic Nano-Particles In and Around Blood Vessels under Applied Magnetic Fields.

Authors:  A Nacev; C Beni; O Bruno; B Shapiro
Journal:  J Magn Magn Mater       Date:  2011-03-01       Impact factor: 2.993

2.  Functionalized iron oxide nanoparticles for controlling the movement of immune cells.

Authors:  Ethan E White; Alex Pai; Yiming Weng; Anil K Suresh; Desiree Van Haute; Torkom Pailevanian; Darya Alizadeh; Ali Hajimiri; Behnam Badie; Jacob M Berlin
Journal:  Nanoscale       Date:  2015-05-07       Impact factor: 7.790

3.  Planar Steering of a Single Ferrofluid Drop by Optimal Minimum Power Dynamic Feedback Control of Four Electromagnets at a Distance.

Authors:  R Probst; J Lin; A Komaee; A Nacev; Z Cummins; B Shapiro
Journal:  J Magn Magn Mater       Date:  2011-04-01       Impact factor: 2.993

Review 4.  Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.

Authors:  Francesca Garello; Yulia Svenskaya; Bogdan Parakhonskiy; Miriam Filippi
Journal:  Pharmaceutics       Date:  2022-05-26       Impact factor: 6.525

Review 5.  Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics: Underlying risks and the emergence of ultrasmall nanomagnets.

Authors:  Divya S Parimi; Yamini Gupta; Sreekar Marpu; Chandra S Bhatt; Tharun K Bollu; Anil K Suresh
Journal:  J Pharm Anal       Date:  2021-11-10

6.  Optimal Halbach Permanent Magnet Designs for Maximally Pulling and Pushing Nanoparticles.

Authors:  A Sarwar; A Nemirovski; B Shapiro
Journal:  J Magn Magn Mater       Date:  2011-09-19       Impact factor: 2.993

Review 7.  Multifunctional nanoparticles for drug delivery and molecular imaging.

Authors:  Gang Bao; Samir Mitragotri; Sheng Tong
Journal:  Annu Rev Biomed Eng       Date:  2013-04-29       Impact factor: 9.590

Review 8.  Magnetic Forces Enable Control of Biological Processes In Vivo.

Authors:  Gang Bao
Journal:  J Appl Mech       Date:  2021-01-12       Impact factor: 2.168

9.  Open challenges in magnetic drug targeting.

Authors:  Benjamin Shapiro; Sandip Kulkarni; Aleksander Nacev; Silvia Muro; Pavel Y Stepanov; Irving N Weinberg
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2014-11-06

10.  A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens.

Authors:  Alek Nacev; Skye H Kim; Jaime Rodriguez-Canales; Michael A Tangrea; Benjamin Shapiro; Michael R Emmert-Buck
Journal:  Int J Nanomedicine       Date:  2011-11-18
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