BACKGROUND: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. AIMS: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. METHODS: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). RESULTS: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. CONCLUSION: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients. Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
BACKGROUND: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. AIMS: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. METHODS: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). RESULTS: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. CONCLUSION: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients. Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Authors: Joanna Raszeja-Wyszomirska; Robert Kucharski; Marta Zygmunt; Krzysztof Safranow; Tomasz Miazgowski Journal: Hepat Mon Date: 2015-04-25 Impact factor: 0.660
Authors: Jennifer Pate; Juilo A Gutierrez; Catherine T Frenette; Aparna Goel; Sonal Kumar; Richard A Manch; Edward A Mena; Paul J Pockros; Sanjaya K Satapathy; Kidist K Yimam; Robert G Gish Journal: BMJ Open Gastroenterol Date: 2019-02-01
Authors: Lorenzo Montali; Andrea Gragnano; Massimo Miglioretti; Alessandra Frigerio; Luca Vecchio; Alessio Gerussi; Laura Cristoferi; Vincenzo Ronca; Daphne D'Amato; Sarah Elizabeth O'Donnell; Clara Mancuso; Martina Lucà; Minami Yagi; Anna Reig; Laura Jopson; Sesé Pilar; Dave Jones; Albert Pares; George Mells; Atsushi Tanaka; Marco Carbone; Pietro Invernizzi Journal: J Transl Autoimmun Date: 2021-01-06
Authors: Joanna Raszeja-Wyszomirska; Ewa Wunsch; Agnieszka Kempinska-Podhorodecka; Daniel S Smyk; Dimitrios P Bogdanos; Malgorzata Milkiewicz; Piotr Milkiewicz Journal: Clin Dev Immunol Date: 2013-04-28
Authors: Ewa Wunsch; Marcin Krawczyk; Malgorzata Milkiewicz; Jocelyn Trottier; Olivier Barbier; Markus F Neurath; Frank Lammert; Andreas E Kremer; Piotr Milkiewicz Journal: Sci Rep Date: 2016-08-10 Impact factor: 4.379