| Literature DB >> 2016305 |
R H Hilderman1, M Martin, J K Zimmerman, E B Pivorun.
Abstract
Adenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) has been implicated as a modulator of cell stress. We have performed binding studies which indicate that membranes from all tissues tested bind tritium-labeled Ap4A. The characteristics of Ap4A binding were determined on brain membrane homogenates after development of an optimized in vitro filter-binding assay. Ap4A binding is specific for adenylated dinucleotides and for the length of the phosphate bridge. A Kd of 0.71 microM for Ap4A was determined.Entities:
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Year: 1991 PMID： 2016305
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157