| Literature DB >> 20162095 |
Mainen J Moshi1, Carolien J P van den Beukel, Omar J M Hamza, Zakaria H Mbwambo, Ramadhani O S Nondo, Pax J Masimba, Mecky I N Matee, Modest C Kapingu, Frans Mikx, Paul E Verweij, André J A M van der Ven.
Abstract
Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC(50) values below 20 microg/ml. These include Aloe lateritia Engl. (Aloaceae) [19.1 microg/ml], Cassia abbreviata Oliv. (Caesalpiniaceae) [12.7 microg/ml], Croton scheffleri Pax (Euphorbiaceae) [13.7 microg/ml], Hymenodactyon parvifolium Brig (Rubiaceae) [13.4 microg/ml], Kigelia Africana L. (Bignoniaceae) [7.2 microg/ml], and Ocimum suave Oliv. (Labiatae) [16.7 microg/ml]. Twelve plants gave LC(50) values between 21 and 50 microg/ml, 11 plants gave LC(50) values between 50 and 100 microg/ml, and 18 plants gave LC(50) values greater than 100 microg/ml.Entities:
Keywords: Brine shrimp test; Toxicity evaluation; Traditional antifungal plants
Year: 2006 PMID： 20162095 PMCID： PMC2816448 DOI： 10.4314/ajtcam.v4i2.31211
Source DB: PubMed Journal: Afr J Tradit Complement Altern Med ISSN： 2505-0044