Literature DB >> 20162052

Antigenotoxic effect of ferulic acid in 7,12-dimethyl benz(a)-anthracene (DMBA) induced genotoxicity.

Subramanian Balakrishnan1, Venugopal P Menon, Shanmugam Manoharan, Kasinathan Rajalingam.   

Abstract

The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg kg(-1) b.w.). Pretreatment of ferulic acid orally at a dose of 40 mg kg(-1) b.w. for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster's bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters.

Entities:  

Keywords:  DMBA; antioxidants; chromosomal aberrations; ferulic acid; genotoxicity; hamster; lipid peroxidation

Year:  2007        PMID： 20162052      PMCID： PMC2816597          DOI： 10.4314/ajtcam.v5i1.31253

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  32 in total

1.  Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase.

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Journal:  Mol Carcinog       Date:  1996-07       Impact factor: 4.784

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  1 in total

1.  Oral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats.

Authors:  Omar S El-Masry; Hussain Abdullah Alhawaj; Muaz O Fagere; Amani Y Owaidah; Aisha Alamri; Khaldoon Alsamman
Journal:  J Exp Pharmacol       Date:  2022-02-25
  1 in total

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