Literature DB >> 20161661

A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation.

Michael Lorenz1, M Shahjahan Kabir, James M Cook.   

Abstract

A general route for the synthesis of biologically important flavones is reported via a two step sequence employing a catalytic Wacker-Cook oxidation4b as the key step.

Entities:  

Year:  2010        PMID： 20161661      PMCID： PMC2818993          DOI： 10.1016/j.tetlet.2009.12.107

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  21 in total

1.  3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

Authors:  X Huang; T Liu; J Gu; X Luo; R Ji; Y Cao; H Xue; J T Wong; B L Wong; G Pei; H Jiang; K Chen
Journal:  J Med Chem       Date:  2001-06-07       Impact factor: 7.446

Review 2.  An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.

Authors:  T Clayton; J L Chen; M Ernst; L Richter; B A Cromer; C J Morton; H Ng; C C Kaczorowski; F J Helmstetter; R Furtmüller; G Ecker; M W Parker; W Sieghart; J M Cook
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.530

3.  Access to flavones via a microwave-assisted, one-pot Sonogashira-carbonylation-annulation reaction.

Authors:  Emelia Awuah; Alfredo Capretta
Journal:  Org Lett       Date:  2009-08-06       Impact factor: 6.005

4.  Triterpenoids and flavonoids from celery (Apium graveolens).

Authors:  Kailan Zhou; Feng Zhao; Zhihui Liu; Yulei Zhuang; Lixia Chen; Feng Qiu
Journal:  J Nat Prod       Date:  2009-09       Impact factor: 4.050

5.  The mechanism of the Wacker reaction: a tale of two hydroxypalladations.

Authors:  John A Keith; Patrick M Henry
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

6.  The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine.

Authors:  Xuebin Liao; Hao Zhou; Xiangyu Z Wearing; Jun Ma; James M Cook
Journal:  Org Lett       Date:  2005-08-04       Impact factor: 6.005

7.  Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

Authors:  Roger J Griffin; Gabriele Fontana; Bernard T Golding; Sophie Guiard; Ian R Hardcastle; Justin J J Leahy; Niall Martin; Caroline Richardson; Laurent Rigoreau; Martin Stockley; Graeme C M Smith
Journal:  J Med Chem       Date:  2005-01-27       Impact factor: 7.446

8.  Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux.

Authors:  Woon Jung Go; Jong Hoon Ryu; Fu Qiang; Hyo-Kyung Han
Journal:  J Nat Prod       Date:  2009-09       Impact factor: 4.050

9.  Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract.

Authors:  H Häberlein; K P Tschiersch; H L Schäfer
Journal:  Pharmazie       Date:  1994-12       Impact factor: 1.267

10.  PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Authors:  Miroslav M Savić; Terry Clayton; Roman Furtmüller; Ivana Gavrilović; Janko Samardzić; Snezana Savić; Sigismund Huck; Werner Sieghart; James M Cook
Journal:  Brain Res       Date:  2008-02-19       Impact factor: 3.252
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