| Literature DB >> 20161175 |
Jeffrey N Anker1, W Paige Hall, Mary P Lambert, Pauline T Velasco, Milan Mrksich, William L Klein, Richard P Van Duyne.
Abstract
High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.Entities:
Year: 2009 PMID: 20161175 PMCID: PMC2723955 DOI: 10.1021/jp900266k
Source DB: PubMed Journal: J Phys Chem C Nanomater Interfaces ISSN: 1932-7447 Impact factor: 4.126