Literature DB >> 20161165

Preparation of the Major Urinary Metabolite of (-)-Prostaglandin E(2).

Douglass F Taber1, Peiming Gu.   

Abstract

The best way to measure whole body production of the locally acting hormone prostaglandin E(2) (PGE(2)) is to assess the accumulation of the major urinary metabolite, PGE(2) U (M). A practical preparation of this delicate diacid is described. This synthetic PGE(2)U(M) will enable production of the antibodies that will be used to quantify this key metabolite.

Entities:  

Year:  2009        PMID： 20161165      PMCID： PMC2719863          DOI： 10.1016/j.tet.2009.05.059

Source DB:  PubMed          Journal:  Tetrahedron        ISSN： 0040-4020            Impact factor:   2.457


  14 in total

1.  A Convenient Method for the Preparation of (Z)-alpha,beta-Unsaturated Carbonyl Compounds.

Authors:  Douglass F. Taber; R. Jason Herr; Shawn K. Pack; John M. Geremia
Journal:  J Org Chem       Date:  1996-04-19       Impact factor: 4.354

2.  Prostaglandin metabolites. Synthesis of E and F urinary metabolites.

Authors:  C H Lin
Journal:  J Org Chem       Date:  1976-12-10       Impact factor: 4.354

3.  Synthesis of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes.

Authors:  Douglass F Taber; Ming Xu; John C Hartnett
Journal:  J Am Chem Soc       Date:  2002-11-06       Impact factor: 15.419

4.  Synthesis of two PGE2 human urinary metabolites.

Authors:  J R Boot; M J Foulis; N J Gutteridge; C W Smith
Journal:  Prostaglandins       Date:  1974-12-10

5.  Cyclopentanone ring formation with control of side chain stereochemistry. A simple stereoselective route to the prostaglandins.

Authors:  D F Taber
Journal:  J Am Chem Soc       Date:  1977-05-11       Impact factor: 15.419

6.  Diastereoselective Synthesis of an Isoprostane: (+/-)-8-epi-PGF(2)(alpha) Ethyl Ester.

Authors:  Douglass F. Taber; R. Jason Herr; D. Mark Gleave
Journal:  J Org Chem       Date:  1997-01-10       Impact factor: 4.354

7.  Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer.

Authors:  Laine J Murphey; Myles K Williams; Stephanie C Sanchez; Loretta M Byrne; Ildiko Csiki; John A Oates; David H Johnson; Jason D Morrow
Journal:  Anal Biochem       Date:  2004-11-15       Impact factor: 3.365

8.  Total synthesis of the ethyl ester of the major urinary metabolite of prostaglandin E(2).

Authors:  Douglass F Taber; Dawei Teng
Journal:  J Org Chem       Date:  2002-03-08       Impact factor: 4.354

9.  A potential route to neuroprostanes and isoprostanes: preparation of the four enantiomerically pure diastereomers of 13-F4t-neuroP.

Authors:  Douglass F Taber; P Ganapati Reddy; Kyle O Arneson
Journal:  J Org Chem       Date:  2008-03-15       Impact factor: 4.354

10.  Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion.

Authors:  Mariam Dohadwala; Raj K Batra; Jie Luo; Ying Lin; Kostyantyn Krysan; Mehis Pold; Sherven Sharma; Steven M Dubinett
Journal:  J Biol Chem       Date:  2002-10-21       Impact factor: 5.157
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  2 in total

1.  Synthesis of tetranor-PGE1: a urinary metabolite of prostaglandins E1 and E2.

Authors:  Jennifer R Kimbrough; Somnath Jana; Kwangho Kim; Alexander Allweil; John A Oates; Ginger L Milne; Gary A Sulikowski
Journal:  Tetrahedron Lett       Date:  2020-04-10       Impact factor: 2.415

2.  Rh-catalyzed intermolecular reactions of cyclic α-diazocarbonyl compounds with selectivity over tertiary C-H bond migration.

Authors:  Andrew DeAngelis; Olga Dmitrenko; Joseph M Fox
Journal:  J Am Chem Soc       Date:  2012-06-19       Impact factor: 15.419
  2 in total

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