Literature DB >> 20160993

Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.

Matthew J Panzner1, Arpaporn Deeraksa, Alyssa Smith, Brian D Wright, Khadijah M Hindi, Aysegul Kascatan-Nebioglu, Alfredo G Torres, Barbara M Judy, Christine E Hovis, Julia K Hilliard, Rebekah J Mallett, Emily Cope, D Mark Estes, Carolyn L Cannon, Jeff G Leid, Wiley J Youngs.   

Abstract

A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.

Entities:  

Year:  2009        PMID： 20160993      PMCID： PMC2755586          DOI： 10.1002/ejic.200801159

Source DB:  PubMed          Journal:  Eur J Inorg Chem        ISSN： 1434-1948            Impact factor:   2.524


  17 in total

Review 1.  Recent advances in our understanding of the use of theophylline in the treatment of asthma.

Authors:  C P Page
Journal:  J Clin Pharmacol       Date:  1999-03       Impact factor: 3.126

Review 2.  Bacterial agents used for bioterrorism.

Authors:  Jan K Horn
Journal:  Surg Infect (Larchmt)       Date:  2003       Impact factor: 2.150

3.  Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.

Authors:  Khadijah M Hindi; Tammy J Siciliano; Semih Durmus; Matthew J Panzner; Doug A Medvetz; D Venkat Reddy; Lisa A Hogue; Christine E Hovis; Julia K Hilliard; Rebekah J Mallet; Claire A Tessier; Carolyn L Cannon; Wiley J Youngs
Journal:  J Med Chem       Date:  2008-02-21       Impact factor: 7.446

4.  Genetic variations in the pgm locus among natural isolates of Yersinia pestis.

Authors:  Zong-Zhong Tong; Dong-Sheng Zhou; Ya-Jun Song; Ling Zhang; Decui Pei; Yan-Ping Han; Xin Pang; Min Li; Bai-Zhong Cui; Jin Wang; Zhao-Biao Guo; Zhi-Zhen Qi; Li-Xia Jin; Jun-Hui Zhai; Zong-Min Du; Xiao-Yi Wang; Jian Wang; Pei-Tang Huang; Huan-Ming Yang; Rui-Fu Yang
Journal:  J Gen Appl Microbiol       Date:  2005-02       Impact factor: 1.452

5.  Human plague in the USA: the importance of regional and local climate.

Authors:  Tamara Ben Ari; Alexander Gershunov; Kenneth L Gage; Tord Snäll; Paul Ettestad; Kyrre L Kausrud; Nils Chr Stenseth
Journal:  Biol Lett       Date:  2008-12-23       Impact factor: 3.703

6.  Invasive methicillin-resistant Staphylococcus aureus infections in the United States.

Authors:  R Monina Klevens; Melissa A Morrison; Joelle Nadle; Susan Petit; Ken Gershman; Susan Ray; Lee H Harrison; Ruth Lynfield; Ghinwa Dumyati; John M Townes; Allen S Craig; Elizabeth R Zell; Gregory E Fosheim; Linda K McDougal; Roberta B Carey; Scott K Fridkin
Journal:  JAMA       Date:  2007-10-17       Impact factor: 56.272

7.  Phenotypic and functional characterization of Bacillus anthracis biofilms.

Authors:  Keehoon Lee; J W Costerton; Jacques Ravel; Raymond K Auerbach; David M Wagner; Paul Keim; Jeff G Leid
Journal:  Microbiology (Reading)       Date:  2007-06       Impact factor: 2.777

Review 8.  Plague.

Authors:  Michael B Prentice; Lila Rahalison
Journal:  Lancet       Date:  2007-04-07       Impact factor: 79.321

Review 9.  Plague: past, present, and future.

Authors:  Nils Chr Stenseth; Bakyt B Atshabar; Mike Begon; Steven R Belmain; Eric Bertherat; Elisabeth Carniel; Kenneth L Gage; Herwig Leirs; Lila Rahalison
Journal:  PLoS Med       Date:  2008-01-15       Impact factor: 11.069

10.  Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.

Authors:  Doug A Medvetz; Khadijah M Hindi; Matthew J Panzner; Andrew J Ditto; Yang H Yun; Wiley J Youngs
Journal:  Met Based Drugs       Date:  2008
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  16 in total

1.  Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria.

Authors:  Brian D Wright; Parth N Shah; Lucas J McDonald; Michael L Shaeffer; Patrick O Wagers; Matthew J Panzner; Justin Smolen; Jasur Tagaev; Claire A Tessier; Carolyn L Cannon; Wiley J Youngs
Journal:  Dalton Trans       Date:  2012-03-08       Impact factor: 4.390

2.  Nanoparticle deposition onto biofilms.

Authors:  J K Miller; R Neubig; C B Clemons; K L Kreider; J P Wilber; G W Young; A J Ditto; Y H Yun; A Milsted; H T Badawy; M J Panzner; W J Youngs; C L Cannon
Journal:  Ann Biomed Eng       Date:  2012-08-10       Impact factor: 3.934

3.  A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens.

Authors:  Matthew J Panzner; Khadijah M Hindi; Brian D Wright; Jane B Taylor; Daniel S Han; Wiley J Youngs; Carolyn L Cannon
Journal:  Dalton Trans       Date:  2009-08-06       Impact factor: 4.390

4.  Preparation and in vitro antimicrobial activity of silver-bearing degradable polymeric nanoparticles of polyphosphoester-block-poly(L-lactide).

Authors:  Young H Lim; Kristin M Tiemann; Gyu Seong Heo; Patrick O Wagers; Yohannes H Rezenom; Shiyi Zhang; Fuwu Zhang; Wiley J Youngs; David A Hunstad; Karen L Wooley
Journal:  ACS Nano       Date:  2015-01-26       Impact factor: 15.881

5.  Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes.

Authors:  Cátia Ornelas-Megiatto; Parth N Shah; Peter R Wich; Jessica L Cohen; Jasur A Tagaev; Justin A Smolen; Brian D Wright; Matthew J Panzner; Wiley J Youngs; Jean M J Fréchet; Carolyn L Cannon
Journal:  Mol Pharm       Date:  2012-10-19       Impact factor: 4.939

6.  Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics.

Authors:  Yali Li; Khadijah Hindi; Kristin M Watts; Jane B Taylor; Ke Zhang; Zicheng Li; David A Hunstad; Carolyn L Cannon; Wiley J Youngs; Karen L Wooley
Journal:  Chem Commun (Camb)       Date:  2009-11-09       Impact factor: 6.222

7.  Modeling the response of a biofilm to silver-based antimicrobial.

Authors:  A E Stine; D Nassar; J K Miller; C B Clemons; J P Wilber; G W Young; Y H Yun; C L Cannon; J G Leid; W J Youngs; A Milsted
Journal:  Math Biosci       Date:  2013-04-27       Impact factor: 2.144

8.  Luminescent di- and polynuclear organometallic gold(I)-metal (Au2, {Au2Ag}n and {Au2Cu}n) compounds containing bidentate phosphanes as active antimicrobial agents.

Authors:  Malgorzata Frik; Josefina Jiménez; Ismael Gracia; Larry R Falvello; Sarya Abi-Habib; Karina Suriel; Theodore R Muth; María Contel
Journal:  Chemistry       Date:  2012-02-14       Impact factor: 5.236

9.  In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria.

Authors:  Jeff G Leid; Andrew J Ditto; Amanda Knapp; Parth N Shah; Brian D Wright; Robyn Blust; Lanette Christensen; C B Clemons; J P Wilber; Gerald W Young; Ae Gyeong Kang; Matthew J Panzner; Carolyn L Cannon; Yang H Yun; Wiley J Youngs; Nicole M Seckinger; Emily K Cope
Journal:  J Antimicrob Chemother       Date:  2011-10-03       Impact factor: 5.790

10.  In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine-silver(I) complex, for treatment of pulmonary infections.

Authors:  Carolyn L Cannon; Lisa A Hogue; Ravy K Vajravelu; George H Capps; Aida Ibricevic; Khadijah M Hindi; Aysegul Kascatan-Nebioglu; Michael J Walter; Steven L Brody; Wiley J Youngs
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191
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