Literature DB >> 20160909

Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(eta-p-cymene)Ru(NS)Cl] (NS = 9-anthraldehyde thiosemicarbazones).

Floyd A Beckford1, Gabriel Leblanc, Jeffrey Thessing, Michael Shaloski, Brian J Frost, Liya Li, Navindra P Seeram.   

Abstract

A series of half-sandwich arene-ruthenium complexes of the type [(eta(6)-p-cymene) Ru(thiosemicarbazone)Cl](+) have been synthesized and their biological activity investigated. The first structurally characterized arene-ruthenium half-sandwich complex with a thiosemicarbazone ligand is reported.

Entities:  

Year:  2009        PMID： 20160909      PMCID： PMC2769075          DOI： 10.1016/j.inoche.2009.08.034

Source DB:  PubMed          Journal:  Inorg Chem Commun        ISSN： 1387-7003            Impact factor:   2.495


  20 in total

1.  Treatment of metastases of solid mouse tumours by NAMI-A: comparison with cisplatin, cyclophosphamide and dacarbazine.

Authors:  G Sava; R Gagliardi; A Bergamo; E Alessio; G Mestroni
Journal:  Anticancer Res       Date:  1999 Mar-Apr       Impact factor: 2.480

2.  Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.

Authors:  Olga Novakova; Jana Kasparkova; Vendula Bursova; Ctirad Hofr; Marie Vojtiskova; Haimei Chen; Peter J Sadler; Viktor Brabec
Journal:  Chem Biol       Date:  2005-01

3.  Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity.

Authors:  Michael Groessl; Erwin Reisner; Christian G Hartinger; Rene Eichinger; Olga Semenova; Andrei R Timerbaev; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Journal:  J Med Chem       Date:  2007-04-03       Impact factor: 7.446

4.  Synthesis and spectroscopic properties of copper(II) complexes derived from thiophene-2-carbaldehyde thiosemicarbazone. Structure and biological activity of [Cu(C6H6N3S2)2].

Authors:  J García-Tojal; A García-Orad; J L Serra; J L Pizarro; L Lezama; M I Arriortua; T Rojo
Journal:  J Inorg Biochem       Date:  1999-05-30       Impact factor: 4.155

5.  DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media.

Authors:  Olga Novakova; Haimei Chen; Oldrich Vrana; Alison Rodger; Peter J Sadler; Viktor Brabec
Journal:  Biochemistry       Date:  2003-10-07       Impact factor: 3.162

6.  Inhibition of cancer cell growth by ruthenium(II) arene complexes.

Authors:  R E Morris; R E Aird; P del S Murdoch; H Chen; J Cummings; N D Hughes; S Parsons; A Parkin; G Boyd; D I Jodrell; P J Sadler
Journal:  J Med Chem       Date:  2001-10-25       Impact factor: 7.446

Review 7.  Ovarian cancer: strategies for overcoming resistance to chemotherapy.

Authors:  Roshan Agarwal; Stan B Kaye
Journal:  Nat Rev Cancer       Date:  2003-07       Impact factor: 60.716

8.  Synergistic antitumor interactions between newly synthesized ruthenium complexes and cytokines in human colon carcinoma cell lines.

Authors:  E D Kreuser; B K Keppler; W E Berdel; A Piest; E Thiel
Journal:  Semin Oncol       Date:  1992-04       Impact factor: 4.929

9.  Studies on the interaction of copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate with calf thymus DNA.

Authors:  Kalyan Sundar Ghosh; Bijaya Ketan Sahoo; Deblina Jana; Swagata Dasgupta
Journal:  J Inorg Biochem       Date:  2008-05-06       Impact factor: 4.155

10.  In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer.

Authors:  R E Aird; J Cummings; A A Ritchie; M Muir; R E Morris; H Chen; P J Sadler; D I Jodrell
Journal:  Br J Cancer       Date:  2002-05-20       Impact factor: 7.640
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  8 in total

1.  Reaction of the Anticancer Organometallic Ruthenium Compound, [(eta-p-Cymene)Ru(ATSC)Cl]PF(6) with Human Serum Albumin.

Authors:  Floyd A Beckford
Journal:  Int J Inorg Chem       Date:  2010-01-01

2.  Synthesis and structure of [(η(6)-p-cymene)Ru(2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl; biological evaluation, topoisomerase II inhibition and reaction with DNA and human serum albumin.

Authors:  Floyd Beckford; Jeffrey Thessing; Jason Woods; Jacob Didion; Nikolay Gerasimchuk; Antonio Gonzalez-Sarrias; Navindra P Seeram
Journal:  Metallomics       Date:  2011-02-23       Impact factor: 4.526

3.  Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules.

Authors:  Floyd A Beckford; Alyssa Brock; Antonio Gonzalez-Sarrías; Navindra P Seeram
Journal:  J Mol Struct       Date:  2016-05-24       Impact factor: 3.196

4.  Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes.

Authors:  Floyd Beckford; Deidra Dourth; Michael Shaloski; Jacob Didion; Jeffrey Thessing; Jason Woods; Vernon Crowell; Nikolay Gerasimchuk; Antonio Gonzalez-Sarrías; Navindra P Seeram
Journal:  J Inorg Biochem       Date:  2011-08       Impact factor: 4.155

5.  Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines.

Authors:  Seminay Guler; Hulya Ayar Kayali; Egemen Orkun Sadan; Betul Sen; Elif Subasi
Journal:  Front Pharmacol       Date:  2022-05-10       Impact factor: 5.988

6.  A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis-Thiocarbohydrazone: Chemical and Biological Investigations.

Authors:  Marianna Pioli; Nicolò Orsoni; Mirco Scaccaglia; Rossella Alinovi; Silvana Pinelli; Giorgio Pelosi; Franco Bisceglie
Journal:  Molecules       Date:  2021-02-10       Impact factor: 4.411

7.  Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity.

Authors:  Anna Gatti; Abraha Habtemariam; Isolda Romero-Canelón; Ji-Inn Song; Bindy Heer; Guy J Clarkson; Dominga Rogolino; Peter J Sadler; Mauro Carcelli
Journal:  Organometallics       Date:  2018-02-20       Impact factor: 3.876

8.  Design, Synthesis, DNA/HSA Binding, and Cytotoxic Activity of Half-Sandwich Ru(II)-Arene Complexes Containing Triarylamine-Thiosemicarbazone Hybrids.

Authors:  Mathiyan Muralisankar; Ramachandran Dheepika; Jebiti Haribabu; Chandrasekar Balachandran; Shin Aoki; Nattamai S P Bhuvanesh; Samuthira Nagarajan
Journal:  ACS Omega       Date:  2019-07-05
  8 in total

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