Literature DB >> 15664521

Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity.

Olga Novakova1, Jana Kasparkova, Vendula Bursova, Ctirad Hofr, Marie Vojtiskova, Haimei Chen, Peter J Sadler, Viktor Brabec.   

Abstract

We analyzed DNA duplexes modified at central guanine residues by monofunctional Ru(II) arene complexes [(eta(6)-arene)Ru(II)(en)(Cl)](+) (arene = tetrahydroanthracene or p-cymene, Ru-THA or Ru-CYM, respectively). These two complexes were chosen as representatives of two different classes of Ru(II) arene compounds for which initial studies revealed different binding modes: one that may involve DNA intercalation (tricyclic-ring Ru-THA) and the other (mono-ring Ru-CYM) that may not. Ru-THA is approximately 20 times more toxic to cancer cells than Ru-CYM. The adducts of Ru-THA and Ru-CYM have contrasting effects on the conformation, thermodynamic stability, and polymerization of DNA in vitro. In addition, the adducts of Ru-CYM are removed from DNA more efficiently than those of Ru-THA. Interestingly, the mammalian nucleotide excision repair system has low efficiency for excision of ruthenium adducts compared to cisplatin intrastrand crosslinks.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15664521     DOI： 10.1016/j.chembiol.2004.11.008

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  23 in total

1.  Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex.

Authors:  Fuyi Wang; Abraha Habtemariam; Erwin P L van der Geer; Robert J Deeth; Robert Gould; Simon Parsons; Peter J Sadler
Journal:  J Biol Inorg Chem       Date:  2009-06-05       Impact factor: 3.358

2.  Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity.

Authors:  Floyd A Beckford; Michael Shaloski; Gabriel Leblanc; Jeffrey Thessing; Lesley C Lewis-Alleyne; Alvin A Holder; Liya Li; Navindra P Seeram
Journal:  Dalton Trans       Date:  2009-09-28       Impact factor: 4.390

3.  Reaction of the Anticancer Organometallic Ruthenium Compound, [(eta-p-Cymene)Ru(ATSC)Cl]PF(6) with Human Serum Albumin.

Authors:  Floyd A Beckford
Journal:  Int J Inorg Chem       Date:  2010-01-01

4.  The interactions of the ruthenium(II)-cymene complexes with lysozyme and cytochrome c.

Authors:  Dragana Stanic-Vucinic; Stefan Nikolic; Katarina Vlajic; Mirjana Radomirovic; Jelena Mihailovic; Tanja Cirkovic Velickovic; Sanja Grguric-Sipka
Journal:  J Biol Inorg Chem       Date:  2020-02-04       Impact factor: 3.358

5.  Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(eta-p-cymene)Ru(NS)Cl] (NS = 9-anthraldehyde thiosemicarbazones).

Authors:  Floyd A Beckford; Gabriel Leblanc; Jeffrey Thessing; Michael Shaloski; Brian J Frost; Liya Li; Navindra P Seeram
Journal:  Inorg Chem Commun       Date:  2009-11-01       Impact factor: 2.495

6.  Biophysical studies on the stability of DNA intrastrand cross-links of transplatin.

Authors:  Jana Kasparkova; Victoria Marini; Vendula Bursova; Viktor Brabec
Journal:  Biophys J       Date:  2008-08-01       Impact factor: 4.033

7.  Effects of the ruthenium-based drug NAMI-A on the roles played by TGF-β1 in the metastatic process.

Authors:  L Brescacin; A Masi; G Sava; A Bergamo
Journal:  J Biol Inorg Chem       Date:  2015-09-14       Impact factor: 3.358

8.  Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes.

Authors:  Maria Castellano-Castillo; Hana Kostrhunova; Victoria Marini; Jana Kasparkova; Peter J Sadler; Jean-Marc Malinge; Viktor Brabec
Journal:  J Biol Inorg Chem       Date:  2008-05-20       Impact factor: 3.358

9.  Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing versus top-down.

Authors:  Kui Wu; Wenbing Hu; Qun Luo; Xianchan Li; Shaoxiang Xiong; Peter J Sadler; Fuyi Wang
Journal:  J Am Soc Mass Spectrom       Date:  2013-02-13       Impact factor: 3.109

10.  Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity.

Authors:  Soledad Betanzos-Lara; Olga Novakova; Robert J Deeth; Ana M Pizarro; Guy J Clarkson; Barbora Liskova; Viktor Brabec; Peter J Sadler; Abraha Habtemariam
Journal:  J Biol Inorg Chem       Date:  2012-07-12       Impact factor: 3.358
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.