BACKGROUND: Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD). METHODS: Thirty-one BD (type I; n = 17 remitted; n = 14 depressed) and 24 age- and gender-ratio-matched healthy individuals (HC) viewed neutral, mild, and intense happy or sad emotional faces in two experiments. The FC was computed as linear and nonlinear dependence measures between amygdala and OFC time series. Effects of group, laterality, and emotion intensity upon amygdala-OFC FC and amygdala-OFC FC white matter fractional anisotropy (FA) relationships were examined. RESULTS: The BD versus HC showed significantly greater right amygdala-OFC FC (p < or = .001) in the sad experiment and significantly reduced bilateral amygdala-OFC FC (p = .007) in the happy experiment. Depressed but not remitted female BD versus female HC showed significantly greater left amygdala-OFC FC (p = .001) to all faces in the sad experiment and reduced bilateral amygdala-OFC FC to intense happy faces (p = .01). There was a significant nonlinear relationship (p = .001) between left amygdala-OFC FC to sad faces and FA in HC. In BD, antidepressants were associated with significantly reduced left amygdala-OFC FC to mild sad faces (p = .001). CONCLUSIONS: In BD, abnormally elevated right amygdala-OFC FC to sad stimuli might represent a trait vulnerability for depression, whereas abnormally elevated left amygdala-OFC FC to sad stimuli and abnormally reduced amygdala-OFC FC to intense happy stimuli might represent a depression state marker. Abnormal FC measures might normalize with antidepressant medications in BD. Nonlinear amygdala-OFC FC-FA relationships in BD and HC require further study. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
BACKGROUND: Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD). METHODS: Thirty-one BD (type I; n = 17 remitted; n = 14 depressed) and 24 age- and gender-ratio-matched healthy individuals (HC) viewed neutral, mild, and intense happy or sad emotional faces in two experiments. The FC was computed as linear and nonlinear dependence measures between amygdala and OFC time series. Effects of group, laterality, and emotion intensity upon amygdala-OFC FC and amygdala-OFC FC white matter fractional anisotropy (FA) relationships were examined. RESULTS: The BD versus HC showed significantly greater right amygdala-OFCFC (p < or = .001) in the sad experiment and significantly reduced bilateral amygdala-OFCFC (p = .007) in the happy experiment. Depressed but not remitted female BD versus female HC showed significantly greater left amygdala-OFCFC (p = .001) to all faces in the sad experiment and reduced bilateral amygdala-OFCFC to intense happy faces (p = .01). There was a significant nonlinear relationship (p = .001) between left amygdala-OFCFC to sad faces and FA in HC. In BD, antidepressants were associated with significantly reduced left amygdala-OFCFC to mild sad faces (p = .001). CONCLUSIONS: In BD, abnormally elevated right amygdala-OFCFC to sad stimuli might represent a trait vulnerability for depression, whereas abnormally elevated left amygdala-OFCFC to sad stimuli and abnormally reduced amygdala-OFCFC to intense happy stimuli might represent a depression state marker. Abnormal FC measures might normalize with antidepressant medications in BD. Nonlinear amygdala-OFCFC-FA relationships in BD and HC require further study. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Authors: Natalia S Lawrence; Andrew M Williams; Simon Surguladze; Vincent Giampietro; Michael J Brammer; Christopher Andrew; Sophia Frangou; Christine Ecker; Mary L Phillips Journal: Biol Psychiatry Date: 2004-03-15 Impact factor: 13.382
Authors: Nathalie Vizueta; Jeffrey D Rudie; Jennifer D Townsend; Salvatore Torrisi; Teena D Moody; Susan Y Bookheimer; Lori L Altshuler Journal: Am J Psychiatry Date: 2012-08 Impact factor: 18.112
Authors: Susan B Perlman; Jorge R C Almeida; Dina M Kronhaus; Amelia Versace; Edmund J Labarbara; Crystal R Klein; Mary L Phillips Journal: Bipolar Disord Date: 2012-03 Impact factor: 6.744
Authors: Aviva K Olsavsky; Melissa A Brotman; Julia G Rutenberg; Eli J Muhrer; Christen M Deveney; Stephen J Fromm; Kenneth Towbin; Daniel S Pine; Ellen Leibenluft Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-01-31 Impact factor: 8.829
Authors: Stephen M Strakowski; James C Eliassen; Martine Lamy; Michael A Cerullo; Jane B Allendorfer; Michelle Madore; Jing-Huei Lee; Jeffrey A Welge; Melissa P DelBello; David E Fleck; Caleb M Adler Journal: Biol Psychiatry Date: 2010-11-03 Impact factor: 13.382
Authors: Amy S Garrett; Allan L Reiss; Meghan E Howe; Ryan G Kelley; Manpreet K Singh; Nancy E Adleman; Asya Karchemskiy; Kiki D Chang Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-06-27 Impact factor: 8.829