Literature DB >> 20157344

Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.

Kay M Brummond1, Jolie E Deforrest.   

Abstract

Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.

Entities:  

Year:  2009        PMID： 20157344      PMCID： PMC2778492          DOI： 10.1055/S-0029-1217183

Source DB:  PubMed          Journal:  Synlett        ISSN： 0936-5214            Impact factor:   2.454


  7 in total

1.  A Dramatic pH Effect Leads to a Catalytic Asymmetric Epoxidation.

Authors:  Zhi-Xian Wang; Yong Tu; Michael Frohn; Yian Shi
Journal:  J Org Chem       Date:  1997-04-18       Impact factor: 4.354

2.  A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.

Authors:  K C Nicolaou; Anthony A Estrada; Mark Zak; Sang Hyup Lee; Brian S Safina
Journal:  Angew Chem Int Ed Engl       Date:  2005-02-18       Impact factor: 15.336

Review 3.  HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.

Authors:  Enzo Tramontano
Journal:  Mini Rev Med Chem       Date:  2006-06       Impact factor: 3.862

Review 4.  Recent progress in the design of small molecule inhibitors of HIV RNase H.

Authors:  Klaus Klumpp; Tara Mirzadegan
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

5.  Novel and efficient syntheses of (-)-methyl 4-epi-shikimate and 4,5-epoxy-quinic and -shikimic acid derivatives as key precursors to prepare new analogues.

Authors:  Laura Sánchez-Abella; Susana Fernández; Nuria Armesto; Miguel Ferrero; Vicente Gotor
Journal:  J Org Chem       Date:  2006-07-07       Impact factor: 4.354

6.  Rapid synthesis of the N-methylwelwitindolinone skeleton.

Authors:  James A MacKay; Raynauld L Bishop; Viresh H Rawal
Journal:  Org Lett       Date:  2005-08-04       Impact factor: 6.005

7.  Cardiovascular effects of new water-soluble derivatives of forskolin.

Authors:  Y Khandelwal; K Rajeshwari; R Rajagopalan; L Swamy; A N Dohadwalla; N J de Souza; R H Rupp
Journal:  J Med Chem       Date:  1988-10       Impact factor: 7.446
  7 in total

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