Literature DB >> 16787384

HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.

Enzo Tramontano1.   

Abstract

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

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Year:  2006        PMID： 16787384     DOI： 10.2174/138955706777435733

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  14 in total

1.  6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.

Authors:  Roberta Costi; Mathieu Métifiot; Francesca Esposito; Giuliana Cuzzucoli Crucitti; Luca Pescatori; Antonella Messore; Luigi Scipione; Silvano Tortorella; Luca Zinzula; Ettore Novellino; Yves Pommier; Enzo Tramontano; Christophe Marchand; Roberto Di Santo
Journal:  J Med Chem       Date:  2013-11-05       Impact factor: 7.446

2.  Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.

Authors:  Giuliana Cuzzucoli Crucitti; Mathieu Métifiot; Luca Pescatori; Antonella Messore; Valentina Noemi Madia; Giovanni Pupo; Francesco Saccoliti; Luigi Scipione; Silvano Tortorella; Francesca Esposito; Angela Corona; Marta Cadeddu; Christophe Marchand; Yves Pommier; Enzo Tramontano; Roberta Costi; Roberto Di Santo
Journal:  J Med Chem       Date:  2015-02-11       Impact factor: 7.446

3.  Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.

Authors:  Francesca Esposito; Tatyana Kharlamova; Simona Distinto; Luca Zinzula; Yung-Chi Cheng; Ginger Dutschman; Giovanni Floris; Patrick Markt; Angela Corona; Enzo Tramontano
Journal:  FEBS J       Date:  2011-03-16       Impact factor: 5.542

4.  Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 RNase H inhibitors.

Authors:  Angela Corona; Anna Schneider; Kristian Schweimer; Paul Rösch; Birgitta M Wöhrl; Enzo Tramontano
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

5.  Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

Authors:  Anna Schneider; Angela Corona; Imke Spöring; Mareike Jordan; Bernd Buchholz; Elias Maccioni; Roberto Di Santo; Jochen Bodem; Enzo Tramontano; Birgitta M Wöhrl
Journal:  Nucleic Acids Res       Date:  2016-02-04       Impact factor: 16.971

6.  Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.

Authors:  Eric B Lansdon; Qi Liu; Stephanie A Leavitt; Mini Balakrishnan; Jason K Perry; Candra Lancaster-Moyer; Nilima Kutty; Xiaohong Liu; Neil H Squires; William J Watkins; Thorsten A Kirschberg
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

7.  Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.

Authors:  Kay M Brummond; Jolie E Deforrest
Journal:  Synlett       Date:  2009-02-11       Impact factor: 2.454

8.  Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives.

Authors:  Angela Corona; Francesco Saverio Di Leva; Sylvain Thierry; Luca Pescatori; Giuliana Cuzzucoli Crucitti; Frederic Subra; Olivier Delelis; Francesca Esposito; Giuseppe Rigogliuso; Roberta Costi; Sandro Cosconati; Ettore Novellino; Roberto Di Santo; Enzo Tramontano
Journal:  Antimicrob Agents Chemother       Date:  2014-08-04       Impact factor: 5.191

9.  Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases H.

Authors:  Sharon J Schultz; Miaohua Zhang; James J Champoux
Journal:  J Biol Chem       Date:  2009-09-24       Impact factor: 5.157

Review 10.  Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

Authors:  Stefan G Sarafianos; Bruno Marchand; Kalyan Das; Daniel M Himmel; Michael A Parniak; Stephen H Hughes; Eddy Arnold
Journal:  J Mol Biol       Date:  2008-11-03       Impact factor: 5.469
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