Literature DB >> 20155915

Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications.

María Angeles Corral-Rodríguez1, Sandra Macedo-Ribeiro, Pedro José Barbosa Pereira, Pablo Fuentes-Prior.   

Abstract

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Year:  2010        PMID： 20155915     DOI： 10.1021/jm901743x

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  16 in total

1.  Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin.

Authors:  Ana Carvalho Figueiredo; Cristina C Clement; Manfred Philipp; Pedro José Barbosa Pereira
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-12-21

2.  Rapid assembly and profiling of an anticoagulant sulfoprotein library.

Authors:  Emma E Watson; Jorge Ripoll-Rozada; Ashley C Lee; Mike C L Wu; Charlotte Franck; Tim Pasch; Bhavesh Premdjee; Jessica Sayers; Maria F Pinto; Pedro M Martins; Shaun P Jackson; Pedro José Barbosa Pereira; Richard J Payne
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-20       Impact factor: 11.205

3.  Hirudins of the Asian medicinal leech, Hirudinaria manillensis: same same, but different.

Authors:  Phil Lukas; Robert Wolf; Bernhard H Rauch; Jan-Peter Hildebrandt; Christian Müller
Journal:  Parasitol Res       Date:  2019-06-11       Impact factor: 2.289

4.  Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors.

Authors:  Robert E Thompson; Xuyu Liu; Jorge Ripoll-Rozada; Noelia Alonso-García; Benjamin L Parker; Pedro José Barbosa Pereira; Richard J Payne
Journal:  Nat Chem       Date:  2017-03-20       Impact factor: 24.427

5.  Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.

Authors:  María Ángeles Corral-Rodríguez; Paul E Bock; Erick Hernández-Carvajal; Ricardo Gutiérrez-Gallego; Pablo Fuentes-Prior
Journal:  Blood       Date:  2011-05-09       Impact factor: 22.113

6.  Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.

Authors:  Ana C Figueiredo; Daniele de Sanctis; Ricardo Gutiérrez-Gallego; Tatiana B Cereija; Sandra Macedo-Ribeiro; Pablo Fuentes-Prior; Pedro José Barbosa Pereira
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-05       Impact factor: 11.205

7.  Highly sensitive optical biosensor for thrombin based on structure switching aptamer-luminescent silica nanoparticles.

Authors:  Ethiraju Babu; Paulpandian Muthu Mareeswaran; Seenivasan Rajagopal
Journal:  J Fluoresc       Date:  2012-09-11       Impact factor: 2.217

Review 8.  Leech therapeutic applications.

Authors:  A M Abdualkader; A M Ghawi; M Alaama; M Awang; A Merzouk
Journal:  Indian J Pharm Sci       Date:  2013-03       Impact factor: 0.975

9.  Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity.

Authors:  Yinong Huang; Yanling Zhang; Bing Zhao; Qiping Xu; Xiushi Zhou; Houyan Song; Min Yu; Wei Mo
Journal:  BMC Struct Biol       Date:  2014-12-20

10.  A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity.

Authors:  Zhuguo Liu; Zheng Yu; Yuanyuan Huang; Yan Zhang; Guozhu Han; Xian Li; Mingxin Dong; Shuo Yu; Yu Wang; Jie Hu; Huiqin Guo; Yuanguo Cheng; Li Lv; Qiuyun Dai
Journal:  Sci Rep       Date:  2015-09-24       Impact factor: 4.379
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