Literature DB >> 20154663

Phenotypic screening: Fishing for neuroactive compounds.

Jeremy L Jenkins1, Laszlo Urban.   

Abstract

Year:  2010        PMID： 20154663     DOI： 10.1038/nchembio.320

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  9 in total

Review 1.  Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.

Authors:  Bryan L Roth; Douglas J Sheffler; Wesley K Kroeze
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

2.  The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Authors:  Justin Lamb; Emily D Crawford; David Peck; Joshua W Modell; Irene C Blat; Matthew J Wrobel; Jim Lerner; Jean-Philippe Brunet; Aravind Subramanian; Kenneth N Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A Armstrong; Stephen J Haggarty; Paul A Clemons; Ru Wei; Steven A Carr; Eric S Lander; Todd R Golub
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

3.  Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Authors:  Daniel W Young; Andreas Bender; Jonathan Hoyt; Elizabeth McWhinnie; Gung-Wei Chirn; Charles Y Tao; John A Tallarico; Mark Labow; Jeremy L Jenkins; Timothy J Mitchison; Yan Feng
Journal:  Nat Chem Biol       Date:  2007-12-09       Impact factor: 15.040

Review 4.  Network pharmacology: the next paradigm in drug discovery.

Authors:  Andrew L Hopkins
Journal:  Nat Chem Biol       Date:  2008-11       Impact factor: 15.040

5.  Predicting new molecular targets for known drugs.

Authors:  Michael J Keiser; Vincent Setola; John J Irwin; Christian Laggner; Atheir I Abbas; Sandra J Hufeisen; Niels H Jensen; Michael B Kuijer; Roberto C Matos; Thuy B Tran; Ryan Whaley; Richard A Glennon; Jérôme Hert; Kelan L H Thomas; Douglas D Edwards; Brian K Shoichet; Bryan L Roth
Journal:  Nature       Date:  2009-11-01       Impact factor: 49.962

6.  In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Authors:  David Plouffe; Achim Brinker; Case McNamara; Kerstin Henson; Nobutaka Kato; Kelli Kuhen; Advait Nagle; Francisco Adrián; Jason T Matzen; Paul Anderson; Tae-Gyu Nam; Nathanael S Gray; Arnab Chatterjee; Jeff Janes; S Frank Yan; Richard Trager; Jeremy S Caldwell; Peter G Schultz; Yingyao Zhou; Elizabeth A Winzeler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

7.  Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.

Authors:  Jason Rihel; David A Prober; Anthony Arvanites; Kelvin Lam; Steven Zimmerman; Sumin Jang; Stephen J Haggarty; David Kokel; Lee L Rubin; Randall T Peterson; Alexander F Schier
Journal:  Science       Date:  2010-01-15       Impact factor: 47.728

Review 8.  Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery.

Authors:  T P Barros; W K Alderton; H M Reynolds; A G Roach; S Berghmans
Journal:  Br J Pharmacol       Date:  2008-06-16       Impact factor: 8.739

9.  Rapid behavior-based identification of neuroactive small molecules in the zebrafish.

Authors:  David Kokel; Jennifer Bryan; Christian Laggner; Rick White; Chung Yan J Cheung; Rita Mateus; David Healey; Sonia Kim; Andreas A Werdich; Stephen J Haggarty; Calum A Macrae; Brian Shoichet; Randall T Peterson
Journal:  Nat Chem Biol       Date:  2010-01-17       Impact factor: 15.040
  9 in total
  2 in total

1.  Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium.

Authors:  Laura Roesler Nery; Natalia Silva Eltz; Cristiana Hackman; Raphaela Fonseca; Stefani Altenhofen; Heydi Noriega Guerra; Vanessa Morais Freitas; Carla Denise Bonan; Monica Ryff Moreira Roca Vianna
Journal:  PLoS One       Date:  2014-09-04       Impact factor: 3.240

Review 2.  Towards High-Throughput Chemobehavioural Phenomics in Neuropsychiatric Drug Discovery.

Authors:  Jason Henry; Donald Wlodkowic
Journal:  Mar Drugs       Date:  2019-06-06       Impact factor: 5.118
  2 in total

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