Literature DB >> 20151021

Photon-Counting H33D Detector for Biological Fluorescence Imaging.

X Michalet1, O H W Siegmund, J V Vallerga, P Jelinsky, J E Millaud, S Weiss.   

Abstract

We have developed a photon-counting High-temporal and High-spatial resolution, High-throughput 3-Dimensional detector (H33D) for biological imaging of fluorescent samples. The design is based on a 25 mm diameter S20 photocathode followed by a 3-microchannel plate stack, and a cross delay line anode. We describe the bench performance of the H33D detector, as well as preliminary imaging results obtained with fluorescent beads, quantum dots and live cells and discuss applications of future generation detectors for single-molecule imaging and high-throughput study of biomolecular interactions.

Entities:  

Year:  2006        PMID： 20151021      PMCID： PMC2819128          DOI： 10.1016/j.nima.2006.05.155

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res A        ISSN： 0168-9002            Impact factor:   1.455


  4 in total

Review 1.  Imaging protein molecules using FRET and FLIM microscopy.

Authors:  Horst Wallrabe; Ammasi Periasamy
Journal:  Curr Opin Biotechnol       Date:  2005-02       Impact factor: 9.740

Review 2.  Quantum dots for live cells, in vivo imaging, and diagnostics.

Authors:  X Michalet; F F Pinaud; L A Bentolila; J M Tsay; S Doose; J J Li; G Sundaresan; A M Wu; S S Gambhir; S Weiss
Journal:  Science       Date:  2005-01-28       Impact factor: 47.728

3.  Time-gated biological imaging by use of colloidal quantum dots.

Authors:  M Dahan; T Laurence; F Pinaud; D S Chemla; A P Alivisatos; M Sauer; S Weiss
Journal:  Opt Lett       Date:  2001-06-01       Impact factor: 3.776

4.  Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides.

Authors:  Fabien Pinaud; David King; Hsiao-Ping Moore; Shimon Weiss
Journal:  J Am Chem Soc       Date:  2004-05-19       Impact factor: 15.419
  4 in total
  15 in total

1.  Phasor imaging with a widefield photon-counting detector.

Authors:  Ryan A Colyer; Oswald H W Siegmund; Anton S Tremsin; John V Vallerga; Shimon Weiss; Xavier Michalet
Journal:  J Biomed Opt       Date:  2012-01       Impact factor: 3.170

2.  Superresolution optical fluctuation imaging with organic dyes.

Authors:  Thomas Dertinger; Mike Heilemann; Robert Vogel; Markus Sauer; Shimon Weiss
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-03       Impact factor: 15.336

3.  Wide-field photon counting fluorescence lifetime imaging microscopy: application to photosynthesizing systems.

Authors:  Zdeněk Petrášek; Hann-Jörg Eckert; Klaus Kemnitz
Journal:  Photosynth Res       Date:  2009 Nov-Dec       Impact factor: 3.573

4.  Hybrid photodetector for single-molecule spectroscopy and microscopy.

Authors:  X Michalet; Adrian Cheng; Joshua Antelman; Motohiro Suyama; Katsushi Arisaka; Shimon Weiss
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2008-02-15

Review 5.  Development of new photon-counting detectors for single-molecule fluorescence microscopy.

Authors:  X Michalet; R A Colyer; G Scalia; A Ingargiola; R Lin; J E Millaud; S Weiss; Oswald H W Siegmund; Anton S Tremsin; John V Vallerga; A Cheng; M Levi; D Aharoni; K Arisaka; F Villa; F Guerrieri; F Panzeri; I Rech; A Gulinatti; F Zappa; M Ghioni; S Cova
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-12-24       Impact factor: 6.237

6.  New photon-counting detectors for single-molecule fluorescence spectroscopy and imaging.

Authors:  X Michalet; R A Colyer; G Scalia; S Weiss; Oswald H W Siegmund; Anton S Tremsin; John V Vallerga; F Villa; F Guerrieri; I Rech; A Gulinatti; S Tisa; F Zappa; M Ghioni; S Cova
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2011-05-13

7.  Development of an ultrafast single photon counting imager for single molecule imaging.

Authors:  Tohru Ohnuki; Xavier Michalet; Arun Tripathi; Shimon Weiss; Katsushi Arisaka
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2006-02

8.  A space- and time-resolved single photon counting detector for fluorescence microscopy and spectroscopy.

Authors:  X Michalet; O H W Siegmund; J V Vallerga; P Jelinsky; J E Millaud; S Weiss
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2006-02

9.  Fluorescence lifetime microscopy with a time- and space-resolved single-photon counting detector.

Authors:  X Michalet; O H W Siegmund; J V Vallerga; P Jelinsky; F F Pinaud; J E Millaud; S Weiss
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2006-10-25

10.  Phasor-based single-molecule fluorescence lifetime imaging using a wide-field photon-counting detector.

Authors:  R Colyer; O Siegmund; A Tremsin; J Vallerga; S Weiss; X Michalet
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2009-01-24
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