OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PATIENTS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719). CONCLUSIONS: Our results presented a highly positive correlation between the combined type of ADHD without co-morbidity and ANKK l (DRD2) polymorphism .
OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHDpatients without co-morbidity. PATIENTS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719). CONCLUSIONS: Our results presented a highly positive correlation between the combined type of ADHD without co-morbidity and ANKK l (DRD2) polymorphism .
Authors: Ananya Roy; Howard Hu; David C Bellinger; Bhramar Mukherjee; Rama Modali; Khaja Nasaruddin; Joel Schwartz; Robert O Wright; Adrienne S Ettinger; Kavitha Palaniapan; Kalpana Balakrishnan Journal: Environ Health Perspect Date: 2011-01 Impact factor: 9.031
Authors: Omar Šerý; Ivo Paclt; Ivana Drtílková; Pavel Theiner; Marta Kopečková; Petr Zvolský; Vladimir J Balcar Journal: Behav Brain Funct Date: 2015-06-11 Impact factor: 3.759
Authors: Anna Grzywacz; Jolanta Chmielowiec; Krzysztof Chmielowiec; Bożena Mroczek; Jolanta Masiak; Aleksandra Suchanecka; Olimpia Sipak-Szmigiel; Kamila Szumilas; Grzegorz Trybek Journal: Int J Environ Res Public Health Date: 2019-07-27 Impact factor: 3.390