Literature DB >> 20150387

The functional role of Notch signaling in human gliomas.

Marie-Thérése Stockhausen1, Karina Kristoffersen, Hans Skovgaard Poulsen.   

Abstract

Gliomas are among the most devastating adult tumors for which there is currently no cure. The tumors are derived from brain glial tissue and comprise several diverse tumor forms and grades. Recent reports highlight the importance of cancer-initiating cells in the malignancy of gliomas. These cells have been referred to as brain cancer stem cells (bCSC), as they share similarities to normal neural stem cells in the brain. The Notch signaling pathway is involved in cell fate decisions throughout normal development and in stem cell proliferation and maintenance. The role of Notch in cancer is now firmly established, and recent data implicate a role for Notch signaling also in gliomas and bCSC. In this review, we explore the role of the Notch signaling pathway in gliomas with emphasis on its role in normal brain development and its interplay with pathways and processes that are characteristic of malignant gliomas.

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Year:  2009        PMID： 20150387      PMCID： PMC2940575          DOI： 10.1093/neuonc/nop022

Source DB:  PubMed          Journal:  Neuro Oncol        ISSN： 1522-8517            Impact factor:   12.300


  108 in total

1.  Direct isolation of human central nervous system stem cells.

Authors:  N Uchida; D W Buck; D He; M J Reitsma; M Masek; T V Phan; A S Tsukamoto; F H Gage; I L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

2.  Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.

Authors:  S J Morrison; S E Perez; Z Qiao; J M Verdi; C Hicks; G Weinmaster; D J Anderson
Journal:  Cell       Date:  2000-05-26       Impact factor: 41.582

3.  Dll4, a novel Notch ligand expressed in arterial endothelium.

Authors:  J R Shutter; S Scully; W Fan; W G Richards; J Kitajewski; G A Deblandre; C R Kintner; K L Stark
Journal:  Genes Dev       Date:  2000-06-01       Impact factor: 11.361

4.  Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development.

Authors:  D K Irvin; S D Zurcher; T Nguyen; G Weinmaster; H I Kornblum
Journal:  J Comp Neurol       Date:  2001-07-23       Impact factor: 3.215

5.  Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.

Authors:  A Rangarajan; C Talora; R Okuyama; M Nicolas; C Mammucari; H Oh; J C Aster; S Krishna; D Metzger; P Chambon; L Miele; M Aguet; F Radtke; G P Dotto
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

6.  Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zone.

Authors:  C S Weickert; M J Webster; S M Colvin; M M Herman; T M Hyde; D R Weinberger; J E Kleinman
Journal:  J Comp Neurol       Date:  2000-07-31       Impact factor: 3.215

7.  Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

Authors:  A Maity; N Pore; J Lee; D Solomon; D M O'Rourke
Journal:  Cancer Res       Date:  2000-10-15       Impact factor: 12.701

8.  Ras pathway signals are required for notch-mediated oncogenesis.

Authors:  K Fitzgerald; A Harrington; P Leder
Journal:  Oncogene       Date:  2000-08-31       Impact factor: 9.867

9.  A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

Authors:  C Brou; F Logeat; N Gupta; C Bessia; O LeBail; J R Doedens; A Cumano; P Roux; R A Black; A Israël
Journal:  Mol Cell       Date:  2000-02       Impact factor: 17.970

10.  A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.

Authors:  J S Mumm; E H Schroeter; M T Saxena; A Griesemer; X Tian; D J Pan; W J Ray; R Kopan
Journal:  Mol Cell       Date:  2000-02       Impact factor: 17.970
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  53 in total

Review 1.  The neurobiology of gliomas: from cell biology to the development of therapeutic approaches.

Authors:  Manfred Westphal; Katrin Lamszus
Journal:  Nat Rev Neurosci       Date:  2011-08-03       Impact factor: 34.870

2.  Study of chromosome 9q gain, Notch pathway regulators and Tenascin-C in ependymomas.

Authors:  Rakesh Kumar Gupta; Mehar C Sharma; Vaishali Suri; Aanchal Kakkar; Manmohan Singh; Chitra Sarkar
Journal:  J Neurooncol       Date:  2013-11-01       Impact factor: 4.130

3.  Tumor stem cells, notch, and the news.

Authors:  W K Alfred Yung
Journal:  Neuro Oncol       Date:  2010-02       Impact factor: 12.300

4.  Dose-dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor.

Authors:  Lan Dai; Jintang He; Yashu Liu; Jaeman Byun; Anuradha Vivekanandan; Subramaniam Pennathur; Xing Fan; David M Lubman
Journal:  Proteomics       Date:  2011-10-24       Impact factor: 3.984

Review 5.  CD133 as a regulator of cancer metastasis through the cancer stem cells.

Authors:  Geou-Yarh Liou
Journal:  Int J Biochem Cell Biol       Date:  2018-11-03       Impact factor: 5.085

Review 6.  MicroRNAs as regulators of neural stem cell-related pathways in glioblastoma multiforme.

Authors:  Pilar González-Gómez; Pilar Sánchez; Helena Mira
Journal:  Mol Neurobiol       Date:  2011-07-05       Impact factor: 5.590

7.  The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study.

Authors:  Jin-Feng Zhang; Yao Chen; Xian-Xin Qiu; Wen-Long Tang; Jian-Dong Zhang; Jian-Huang Huang; Guo-Shi Lin; Xing-Fu Wang; Zhi-Xiong Lin
Journal:  Tumour Biol       Date:  2015-10-15

8.  Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.

Authors:  Shingo Tanaka; Mitsutoshi Nakada; Daisuke Yamada; Ichiro Nakano; Tomoki Todo; Yasushi Ino; Takayuki Hoshii; Yuko Tadokoro; Kumiko Ohta; Mohamed A E Ali; Yutaka Hayashi; Jun-ichiro Hamada; Atsushi Hirao
Journal:  J Neurooncol       Date:  2014-10-08       Impact factor: 4.130

Review 9.  Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.

Authors:  Zhiwei Wang; Hiroyuki Inuzuka; Hidefumi Fukushima; Lixin Wan; Daming Gao; Shavali Shaik; Fazlul H Sarkar; Wenyi Wei
Journal:  EMBO Rep       Date:  2011-12-23       Impact factor: 8.807

10.  HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells.

Authors:  Jessica Tilghman; Hao Wu; Yingying Sang; Xiaohai Shi; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa; Charles G Eberhart; John Laterra; Mingyao Ying
Journal:  Cancer Res       Date:  2014-04-07       Impact factor: 12.701
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