| Literature DB >> 20149612 |
N B Pinto1, T C Morais, K M B Carvalho, C R Silva, G M Andrade, G A C Brito, M L Veras, O D L Pessoa, V S Rao, F A Santos.
Abstract
The anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF-alpha and IFN-gamma), myeloperoxidase (MPO) activity, and histological and immunohistochemical findings were analysed, as indicators of dermal inflammation. Similar to dexamethasone, topically applied Physalin E (0.125; 0.25 and 0.5 mg/ear) potently inhibited the TPA and oxazolone-induced dermatitis, leading to substantial reductions in ear edema/thickness, pro-inflammatory cytokines, and MPO activity. These effects were reversed by mifepristone, a steroid antagonist and confirmed by immunohistochemical and histopathological analysis. The data suggest that physalin E may be a potent and topically effective anti-inflammatory agent useful to treat the acute and chronic skin inflammatory conditions. 2010 Elsevier GmbH. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20149612 DOI： 10.1016/j.phymed.2010.01.006
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340