Literature DB >> 20149488

Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide.

Mosaad S M Abd Alla1, Mohamed I Hegab, Nageh A Abo Taleb, Sherifa M Hasabelnaby, A Goudah.   

Abstract

Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, (1)H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID: 20149488     DOI: 10.1016/j.ejmech.2009.10.028

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  5 in total

1.  4-(4-Methyl-phen-yl)-2-(prop-2-yn-1-yl)phthalazin-1(2H)-one.

Authors:  M K Usha; S Madan Kumar; P C Shyma; B Kalluraya; N K Lokanath; D Revannasiddaiah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-01-15

2.  Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives.

Authors:  Irina Zarafu; Lilia Matei; Coralia Bleotu; Petre Ionita; Arnaud Tatibouët; Anca Păun; Ioana Nicolau; Anamaria Hanganu; Carmen Limban; Diana Camelia Nuta; Roxana Maria Nemeș; Carmen Cristina Diaconu; Cristiana Radulescu
Journal:  Molecules       Date:  2020-07-21       Impact factor: 4.411

3.  An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation.

Authors:  Fatma S Elsharabasy; Sobhi M Gomha; Thoraya A Farghaly; Heba S A Elzahabi
Journal:  Molecules       Date:  2017-02-18       Impact factor: 4.411

4.  Design, facile synthesis and anthelmintic activity of new O-substituted 6-methoxybenzothiazole-2-carbamates. Part II.

Authors:  A Mohsen M E Omar; Omaima M Aboulwafa; Doaa A E Issa; Mai S M El-Shoukrofy; May E Amr; Ibrahim M El-Ashmawy
Journal:  Medchemcomm       Date:  2017-05-12       Impact factor: 3.597

5.  Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes.

Authors:  Ahmed T A Boraei; El Sayed H El Ashry; Axel Duerkop
Journal:  Chem Cent J       Date:  2016-04-27       Impact factor: 4.215

  5 in total

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