PURPOSE: To estimate the 4-year incidence and progression of diabetic retinopathy, macular edema (ME) and clinically significant macular edema (CSME) among adult Latinos with diabetes mellitus. DESIGN: A population-based, longitudinal study of 4658 self-identified Latinos (primarily Mexican Americans), residing in Los Angeles, examined at baseline (2000-2003) and at 4 years (2004-2008). METHODS: Participants underwent a standardized ophthalmic examination. Diabetic retinopathy (DR) and CSME were detected by grading of stereoscopic fundus photographs using the modified Airlie House classification scheme. chi(2) and trend tests were used to assess differences in incidence when stratifying by age and duration of diabetes. RESULTS: The 4-year incidence of DR, ME, and CSME was 34.0% (182/535), 5.4% (38/699), and 7.2% (50/699) respectively. Younger persons and those with longer duration of diabetes mellitus had a higher incidence of DR compared to those who were older and had shorter duration of diabetes mellitus. A higher incidence of ME was associated with longer duration of diabetes mellitus (P = .004). Worsening/progression of any DR was found in 38.9% (126/324) and improvement occurred in 14.0% (37/265) of participants. Progression from nonproliferative DR (NPDR) to proliferative DR (PDR) and from NPDR to PDR with high-risk characteristics occurred in 5.3% and 1.9% of participants. CONCLUSIONS: The 4-year incidence and progression of DR and the incidence of ME and CSME among Latinos are high compared to non-Hispanic whites. These findings support the need to identify and modify risk factors associated with these long-term complications. Copyright 2010 Elsevier Inc. All rights reserved.
PURPOSE: To estimate the 4-year incidence and progression of diabetic retinopathy, macular edema (ME) and clinically significant macular edema (CSME) among adult Latinos with diabetes mellitus. DESIGN: A population-based, longitudinal study of 4658 self-identified Latinos (primarily Mexican Americans), residing in Los Angeles, examined at baseline (2000-2003) and at 4 years (2004-2008). METHODS:Participants underwent a standardized ophthalmic examination. Diabetic retinopathy (DR) and CSME were detected by grading of stereoscopic fundus photographs using the modified Airlie House classification scheme. chi(2) and trend tests were used to assess differences in incidence when stratifying by age and duration of diabetes. RESULTS: The 4-year incidence of DR, ME, and CSME was 34.0% (182/535), 5.4% (38/699), and 7.2% (50/699) respectively. Younger persons and those with longer duration of diabetes mellitus had a higher incidence of DR compared to those who were older and had shorter duration of diabetes mellitus. A higher incidence of ME was associated with longer duration of diabetes mellitus (P = .004). Worsening/progression of any DR was found in 38.9% (126/324) and improvement occurred in 14.0% (37/265) of participants. Progression from nonproliferative DR (NPDR) to proliferative DR (PDR) and from NPDR to PDR with high-risk characteristics occurred in 5.3% and 1.9% of participants. CONCLUSIONS: The 4-year incidence and progression of DR and the incidence of ME and CSME among Latinos are high compared to non-Hispanic whites. These findings support the need to identify and modify risk factors associated with these long-term complications. Copyright 2010 Elsevier Inc. All rights reserved.
Authors: Rohit Varma; Sylvia H Paz; Stanley P Azen; Ronald Klein; Denise Globe; Mina Torres; Chrisandra Shufelt; Susan Preston-Martin Journal: Ophthalmology Date: 2004-06 Impact factor: 12.079
Authors: Robyn J Tapp; Gabriella Tikellis; Tien Y Wong; C Alex Harper; Paul Z Zimmet; Jonathan E Shaw Journal: Diabetes Care Date: 2008-04-14 Impact factor: 19.112
Authors: R Kawasaki; S Tanaka; S Tanaka; T Yamamoto; H Sone; Y Ohashi; Y Akanuma; N Yamada; H Yamashita Journal: Diabetologia Date: 2011-06-01 Impact factor: 10.122
Authors: Farzana Choudhury; Rohit Varma; Roberta McKean-Cowdin; Ronald Klein; Stanley P Azen Journal: Am J Ophthalmol Date: 2011-06-16 Impact factor: 5.258
Authors: Xiaoyi Gao; W James Gauderman; Paul Marjoram; Mina Torres; Yii-Der I Chen; Kent D Taylor; Jerome I Rotter; Rohit Varma Journal: Invest Ophthalmol Vis Sci Date: 2014-08-21 Impact factor: 4.799
Authors: Eugene J Barrett; Zhenqi Liu; Mogher Khamaisi; George L King; Ronald Klein; Barbara E K Klein; Timothy M Hughes; Suzanne Craft; Barry I Freedman; Donald W Bowden; Aaron I Vinik; Carolina M Casellini Journal: J Clin Endocrinol Metab Date: 2017-12-01 Impact factor: 5.958
Authors: Jane Z Kuo; Xiuqing Guo; Ronald Klein; Barbara E Klein; Jinrui Cui; Jerome I Rotter; Eli Ipp; Yii-Der Ida Chen Journal: Ophthalmology Date: 2012-02-11 Impact factor: 12.079
Authors: Wayne H-H Sheu; Jane Z Kuo; I-Te Lee; Yi-Jen Hung; Wen-Jane Lee; Hin-Yeung Tsai; J-S Wang; Mark O Goodarzi; Ronald Klein; Barbara E K Klein; Eli Ipp; Shin-Yi Lin; Xiuqing Guo; Chang-Hsun Hsieh; Kent D Taylor; Chia-Po Fu; Jerome I Rotter; Yii-Der I Chen Journal: Hum Mol Genet Date: 2013-04-04 Impact factor: 6.150