AIM: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcgamma receptor (FcgammaR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. MATERIALS AND METHODS: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcgammaRIIA H131R (rs1801274), FcgammaRIIIA F158V (rs396991) and FcgammaRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. RESULTS AND CONCLUSIONS: The FcgammaRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcgammaRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcgammaRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcgammaRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking).
AIM: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcgamma receptor (FcgammaR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. MATERIALS AND METHODS: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcgammaRIIA H131R (rs1801274), FcgammaRIIIA F158V (rs396991) and FcgammaRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. RESULTS AND CONCLUSIONS: The FcgammaRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcgammaRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcgammaRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcgammaRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking).
Authors: Jamal M Stein; Helmut K G Machulla; James Deschner; Stefan Fickl; Yvonne Jockel-Schneider; Miriam Tamm; Susanne Schulz; Stefan Reichert Journal: Clin Oral Investig Date: 2015-08-26 Impact factor: 3.573
Authors: Bright Adu; Daniel Dodoo; Selorme Adukpo; Paula L Hedley; Fareed K N Arthur; Thomas A Gerds; Severin O Larsen; Michael Christiansen; Michael Theisen Journal: PLoS One Date: 2012-09-25 Impact factor: 3.240
Authors: Harshada K Kangne; Farah F Jijina; Yazdi M Italia; Dipti L Jain; Anita H Nadkarni; Maya Gupta; Vandana Pradhan; Rati D Mukesh; Kanjaksha K Ghosh; Roshan B Colah Journal: Biomed Res Int Date: 2013-09-29 Impact factor: 3.411
Authors: X Wu; S Offenbacher; N J Lόpez; D Chen; H-Y Wang; J Rogus; J Zhou; J Beck; S Jiang; X Bao; L Wilkins; L Doucette-Stamm; K Kornman Journal: J Periodontal Res Date: 2014-04-02 Impact factor: 4.419