Jamal M Stein1, Helmut K G Machulla2, James Deschner3, Stefan Fickl4, Yvonne Jockel-Schneider4, Miriam Tamm5, Susanne Schulz6, Stefan Reichert6. 1. Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital (RWTH) Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. JStein@ukaachen.de. 2. Institute of Physiology, University of the Saarland, Kirrberger Straße 100, 66424, Homburg/Saar, Germany. 3. Section of Experimental Dento-Maxillo-Facial Medicine, University of Bonn, Welschnonnenstraße 17, 53111, Bonn, Germany. 4. Department of Periodontology, University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany. 5. Department of Medical Statistics, University Hospital (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. 6. Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Große Steinstraße 19, 06108, Halle (Saale), Germany.
Abstract
OBJECTIVE: Human leukocyte antigens (HLA) have been associated with periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. The aim of the study was to verify these associations in a group of HLA-typed blood donors with previously unknown periodontal status. MATERIALS AND METHODS: In four German centers, 140 blood donors with known HLA class I status were enrolled and allocated to the following five groups: HLA-A9 (N = 24), HLA-B15 (N = 20), HLA-A2 (N = 30), HLA-B5 (N = 26), and controls (N = 40). Periodontal examination included the measurement of probing depths (PDs), clinical attachment level (CAL), bleeding on probing (BOP), and community periodontal index of treatment needs (CPITN). RESULTS: Carriers with HLA-A9 and HLA-B15 had higher values of mean PD (P < 0.0001), CAL (P < 0.0001), and BOP (P < 0.002) as well as sites with PD and CAL with ≥4 and ≥6 mm (P < 0.0003), respectively, than controls. Multiple regression analyses revealed HLA-A9, HLA-B15, and smoking as risk indicators for moderate to severe (CPITN 3-4; odds ratio (OR): 66.7, 15.3, and 5.1) and severe (CPITN 4; OR: 6.6, 7.4, and 3.8) periodontitis. HLA-A2 and HLA-B5 did not show any relevant associations. CONCLUSION: The present data support a role of HLA-A9 and HLA-B15 as susceptibility factors for periodontitis, whereas HLA-A2 and HLA-B5 could not be confirmed as resistance factors. CLINICAL RELEVANCE: Both HLA antigens A9 and B15 are potential candidates for periodontal risk assessment.
OBJECTIVE:Human leukocyte antigens (HLA) have been associated with periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. The aim of the study was to verify these associations in a group of HLA-typed blood donors with previously unknown periodontal status. MATERIALS AND METHODS: In four German centers, 140 blood donors with known HLA class I status were enrolled and allocated to the following five groups: HLA-A9 (N = 24), HLA-B15 (N = 20), HLA-A2 (N = 30), HLA-B5 (N = 26), and controls (N = 40). Periodontal examination included the measurement of probing depths (PDs), clinical attachment level (CAL), bleeding on probing (BOP), and community periodontal index of treatment needs (CPITN). RESULTS: Carriers with HLA-A9 and HLA-B15 had higher values of mean PD (P < 0.0001), CAL (P < 0.0001), and BOP (P < 0.002) as well as sites with PD and CAL with ≥4 and ≥6 mm (P < 0.0003), respectively, than controls. Multiple regression analyses revealed HLA-A9, HLA-B15, and smoking as risk indicators for moderate to severe (CPITN 3-4; odds ratio (OR): 66.7, 15.3, and 5.1) and severe (CPITN 4; OR: 6.6, 7.4, and 3.8) periodontitis. HLA-A2 and HLA-B5 did not show any relevant associations. CONCLUSION: The present data support a role of HLA-A9 and HLA-B15 as susceptibility factors for periodontitis, whereas HLA-A2 and HLA-B5 could not be confirmed as resistance factors. CLINICAL RELEVANCE: Both HLA antigens A9 and B15 are potential candidates for periodontal risk assessment.
Entities:
Keywords:
HLA; Major histocompatibility complex; Periodontitis; Risk factors
Authors: B S Michalowicz; S R Diehl; J C Gunsolley; B S Sparks; C N Brooks; T E Koertge; J V Califano; J A Burmeister; H A Schenkein Journal: J Periodontol Date: 2000-11 Impact factor: 6.993