| Literature DB >> 20148885 |
Giovanni Del Poeta1, Emanuele Ammatuna, Serena Lavorgna, Giovanni Capelli, Serena Zaza, Fabrizio Luciano, Tiziana Ottone, Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Paola Panetta, Paolo de Fabritiis, Roberto Stasi, Adriano Venditti, Sergio Amadori, Francesco Lo Coco.
Abstract
Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio >0.35 and NPM1 without FLT3-ITD were significantly associated (P = 0.0001). NPM1-mutated (mt)/FLT3-ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0.0002) and a longer overall survival (OS, P = 0.00007). NPM1-mt/FLT3-ITD negative plus bax/bcl-2 > 0.35 subset showed a very high CR rate (96%), very long OS (P = 0.00005) and disease-free survival (P = 0.004). The favourable prognosis of NPM1-mt/FLT3-ITD negative patients might be explained by a higher bax/bcl-2 ratio.Entities:
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Year: 2010 PMID： 20148885 DOI： 10.1111/j.1365-2141.2010.08098.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998