Literature DB >> 2014649

Proteolysis at the 2A/2B junction in Theiler's murine encephalomyelitis virus.

S Batson1, K Rundell.   

Abstract

Processing at the 2A/2B junction in Theiler's murine encephalomyelitis virus (TMEV) was studied using in vitro transcription and translation. A plasmid which contained only the P2 region of TMEV was used. The protein products obtained after in vitro transcription/translation indicated that proteolysis at the 2A/2B junction occurs even if templates coding for only the 2A and 2B proteins are used. Time-course experiments indicated that 2A/2B proteolysis was cotranslational. The plasmid described will allow further definition of the sequences involved in this proteolytic event.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 2014649     DOI： 10.1016/0042-6822(91)90914-w

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  9 in total

1.  Deletion mapping of the encephalomyocarditis virus primary cleavage site.

Authors:  H Hahn; A C Palmenberg
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

Review 2.  Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

Authors:  W G Dougherty; B L Semler
Journal:  Microbiol Rev       Date:  1993-12

3.  Mutational analysis of the encephalomyocarditis virus primary cleavage.

Authors:  H Hahn; A C Palmenberg
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

4.  Protein 2A is not required for Theiler's virus replication.

Authors:  T Michiels; V Dejong; R Rodrigus; C Shaw-Jackson
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

5.  Theiler's murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism.

Authors:  G Loughran; J E Libbey; S Uddowla; M F Scallan; M D Ryan; R S Fujinami; E Rieder; J F Atkins
Journal:  J Gen Virol       Date:  2012-10-24       Impact factor: 3.891

6.  Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome.

Authors:  Gary Loughran; Andrew E Firth; John F Atkins
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-24       Impact factor: 11.205

7.  Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus.

Authors:  Leanne K Finch; Roger Ling; Sawsan Napthine; Allan Olspert; Thomas Michiels; Cécile Lardinois; Susanne Bell; Gary Loughran; Ian Brierley; Andew E Firth
Journal:  J Virol       Date:  2015-08       Impact factor: 5.103

8.  Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.

Authors:  Chris H Hill; Georgia M Cook; Sawsan Napthine; Anuja Kibe; Katherine Brown; Neva Caliskan; Andrew E Firth; Stephen C Graham; Ian Brierley
Journal:  Nucleic Acids Res       Date:  2021-11-18       Impact factor: 16.971

9.  Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.

Authors:  M D Ryan; J Drew
Journal:  EMBO J       Date:  1994-02-15       Impact factor: 11.598
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.