Literature DB >> 2014260

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

S Radovick1, S Wray, E Lee, D K Nicols, Y Nakayama, B D Weintraub, H Westphal, G B Cutler, F E Wondisford.   

Abstract

Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development, central hypogonadism in humans could be caused by failure in normal migration of GnRH neurons to the hypothalamus. We report that in transgenic mice expression of the simian virus 40 T antigen, driven by the promoter of human GnRH gene, resulted in central hypogonadism due to an arrest in neuronal migration during development and tumor formation along the migratory pathway. This system appears to be an important animal model of hypogonadotropic hypogonadism in humans. Additionally, olfactory bulb tumors from these animals were dispersed, and a GnRH-secreting neuronal cell line (GN cell line) was established.

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Year:  1991        PMID： 2014260      PMCID： PMC51455          DOI： 10.1073/pnas.88.8.3402

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

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Journal:  Neuron       Date:  1990-07       Impact factor: 17.173

Review 2.  The mammalian GnRH gene and its pivotal role in reproduction.

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Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

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Journal:  Science       Date:  1986-12-12       Impact factor: 47.728

5.  Oncogenesis of the lens in transgenic mice.

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Journal:  Science       Date:  1987-03-27       Impact factor: 47.728

6.  Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.

Authors:  S Radovick; F E Wondisford; Y Nakayama; M Yamada; G B Cutler; B D Weintraub
Journal:  Mol Endocrinol       Date:  1990-03

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Authors:  M Schwanzel-Fukuda; D W Pfaff
Journal:  Nature       Date:  1989-03-09       Impact factor: 49.962

8.  Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode.

Authors:  S Wray; P Grant; H Gainer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

Review 9.  Transgenic mice as probes into complex systems.

Authors:  D Hanahan
Journal:  Science       Date:  1989-12-08       Impact factor: 47.728

10.  Spatiotemporal cell expression of luteinizing hormone-releasing hormone in the prenatal mouse: evidence for an embryonic origin in the olfactory placode.

Authors:  S Wray; A Nieburgs; S Elkabes
Journal:  Brain Res Dev Brain Res       Date:  1989-04-01
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  76 in total

1.  Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements.

Authors:  Carolyn G Kelley; Marjory L Givens; Naama Rave-Harel; Shelley B Nelson; Scott Anderson; Pamela L Mellon
Journal:  Mol Endocrinol       Date:  2002-11

Review 2.  Identified GnRH neuron electrophysiology: a decade of study.

Authors:  Suzanne M Moenter
Journal:  Brain Res       Date:  2010-11-01       Impact factor: 3.252

3.  Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression.

Authors:  Anita K Iyer; Nichol L G Miller; Kathleen Yip; Brian H Tran; Pamela L Mellon
Journal:  Mol Endocrinol       Date:  2010-07-28

4.  Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase.

Authors:  Melissa P Allen; Daniel A Linseman; Hiroshi Udo; Mei Xu; Jerome B Schaack; Brian Varnum; Eric R Kandel; Kim A Heidenreich; Margaret E Wierman
Journal:  Mol Cell Biol       Date:  2002-01       Impact factor: 4.272

Review 5.  The glycosphingolipid hydrolases in the central nervous system.

Authors:  Massimo Aureli; Maura Samarani; Nicoletta Loberto; Rosaria Bassi; Valentina Murdica; Simona Prioni; Alessandro Prinetti; Sandro Sonnino
Journal:  Mol Neurobiol       Date:  2013-11-27       Impact factor: 5.590

6.  Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families.

Authors:  Marjory L Givens; Naama Rave-Harel; Vinodha D Goonewardena; Reiko Kurotani; Sara E Berdy; Christo H Swan; John L R Rubenstein; Benoit Robert; Pamela L Mellon
Journal:  J Biol Chem       Date:  2005-03-01       Impact factor: 5.157

7.  NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

Authors:  Benoît Schneider; Vincent Mutel; Mathéa Pietri; Myriam Ermonval; Sophie Mouillet-Richard; Odile Kellermann
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

8.  Myo10 is required for neurogenic cell adhesion and migration.

Authors:  Huali Yu; Mingming Lai; Yuguang Guo; Lin Yuan; Yongsheng Lan; Xingzhi Wang; Xiaojuan Zhu
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-12-10       Impact factor: 2.416

Review 9.  Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells.

Authors:  M E Wierman; J M Bruder; J K Kepa
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

Review 10.  Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology.

Authors:  W C Wetsel
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046
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