Jin Liang Zhu1, Carsten Obel, Olga Basso, Jørn Olsen. 1. The Danish Epidemiology Science Centre, Department of Epidemiology, School of Public Health, University of Aarhus, Bartholins Allé 2, 8000 Aarhus C, Denmark. zjl@soci.au.dk
Abstract
BACKGROUND: It has previously been reported that children born after infertility treatment had a slight delay in early motor milestones. In this study, we examined whether children of infertile couples with or without infertility treatment had a higher risk of developmental coordination disorder (DCD). METHODS: We used data on parental infertility and DCD among 23 167 singletons from the Danish National Birth Cohort (1996-2002). Data on time to pregnancy (TTP) and infertility treatment were collected early in pregnancy. Data on DCD in children were collected using the Developmental Coordination Disorder Questionnaire, filled in by the mothers during follow-up when the children were 7 years old. We used the recommended cut-off for the age group to classify children. RESULTS: Compared with children born of fertile couples, children conceived after a waiting TTP of longer than 12 months had a slightly higher risk of DCD [odds ratio (OR) 1.35, 95% confidence interval (CI) 1.03-1.77], but the estimated OR was not significant in children born after infertility treatment (OR 1.19, 95% CI 0.86-1.66). None of the individual treatment procedures was significantly associated with a higher risk of DCD. Children of parents who had not planned their pregnancy showed no elevated risk. CONCLUSIONS: Our findings are overall reassuring, although it is possible that low fecundity may be associated with a modestly increased risk of DCD.
BACKGROUND: It has previously been reported that children born after infertility treatment had a slight delay in early motor milestones. In this study, we examined whether children of infertile couples with or without infertility treatment had a higher risk of developmental coordination disorder (DCD). METHODS: We used data on parental infertility and DCD among 23 167 singletons from the Danish National Birth Cohort (1996-2002). Data on time to pregnancy (TTP) and infertility treatment were collected early in pregnancy. Data on DCD in children were collected using the Developmental Coordination Disorder Questionnaire, filled in by the mothers during follow-up when the children were 7 years old. We used the recommended cut-off for the age group to classify children. RESULTS: Compared with children born of fertile couples, children conceived after a waiting TTP of longer than 12 months had a slightly higher risk of DCD [odds ratio (OR) 1.35, 95% confidence interval (CI) 1.03-1.77], but the estimated OR was not significant in children born after infertility treatment (OR 1.19, 95% CI 0.86-1.66). None of the individual treatment procedures was significantly associated with a higher risk of DCD. Children of parents who had not planned their pregnancy showed no elevated risk. CONCLUSIONS: Our findings are overall reassuring, although it is possible that low fecundity may be associated with a modestly increased risk of DCD.
Authors: J Olsen; M Melbye; S F Olsen; T I Sørensen; P Aaby; A M Andersen; D Taxbøl; K D Hansen; M Juhl; T B Schow; H T Sørensen; J Andresen; E L Mortensen; A W Olesen; C Søndergaard Journal: Scand J Public Health Date: 2001-12 Impact factor: 3.021
Authors: Jessika F van Hoorn; Marina M Schoemaker; Ilse Stuive; Pieter U Dijkstra; Francisca Rodrigues Trigo Pereira; Corry K van der Sluis; Mijna Hadders-Algra Journal: Dev Med Child Neurol Date: 2020-12-20 Impact factor: 5.449