Effect of aspirin, other NSAIDs, and statins on PSA and PSA velocity.

BACKGROUND: Aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), and statins have been associated with lower risk of prostate cancer and its progression, though results have been inconsistent.
METHODS: Data from 140 men with prostate cancer enrolled in a Phase 2 clinical trial of selenium to prevent prostate cancer progression were analyzed to determine association between aspirin, other NSAIDs, or statin use with baseline serum prostate-specific antigen (PSA) levels and PSA velocity (rate of PSA change over time) using repeated measures over an average follow-up time of 3.2 years. Multiple linear regression and mixed effects models were used to model the association of medication use with PSA at baseline and with PSA velocity, respectively.
RESULTS: Baseline PSA levels were significantly lower in aspirin users compared to non-users (5.17 ng/ml vs. 7.58 ng/ml, P = 0.001). This association was statistically significant in never smokers (aspirin users vs. non-users: 4.19 ng/ml vs. 8.24 ng/ml, P = 0.004) but not in ever smokers (aspirin users vs. non-users: 5.52 ng/ml vs. 7.3 ng/ml, P = 0.101). Statin and other NSAID use was not associated with baseline PSA. Aspirin, statin, or other NSAID use at baseline demonstrated a non-significant negative association with PSA velocity.
CONCLUSION: These findings support an effect of aspirin use on PSA, particularly among never smokers. However, they do not suggest a protective effect on the disease and support previous findings that aspirin use may mask accurate measurement of PSA warranting consideration of washout procedures prior to testing.

RCT Entities:   Population Interventions Outcomes