Inflammation in the etiology of prostate cancer: an epidemiologic perspective.

The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.