Literature DB >> 20133523

Regulation of alternative splicing by histone modifications.

Reini F Luco1, Qun Pan, Kaoru Tominaga, Benjamin J Blencowe, Olivia M Pereira-Smith, Tom Misteli.   

Abstract

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.

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Year:  2010        PMID： 20133523      PMCID： PMC2913848          DOI： 10.1126/science.1184208

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  A slow RNA polymerase II affects alternative splicing in vivo.

Authors:  Manuel de la Mata; Claudio R Alonso; Sebastián Kadener; Juan P Fededa; Matías Blaustein; Federico Pelisch; Paula Cramer; David Bentley; Alberto R Kornblihtt
Journal:  Mol Cell       Date:  2003-08       Impact factor: 17.970

Review 2.  Multiple links between transcription and splicing.

Authors:  Alberto R Kornblihtt; Manuel de la Mata; Juan Pablo Fededa; Manuel J Munoz; Guadalupe Nogues
Journal:  RNA       Date:  2004-10       Impact factor: 4.942

3.  Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform.

Authors:  Qun Pan; Ofer Shai; Christine Misquitta; Wen Zhang; Arneet L Saltzman; Naveed Mohammad; Tomas Babak; Henry Siu; Timothy R Hughes; Quaid D Morris; Brendan J Frey; Benjamin J Blencowe
Journal:  Mol Cell       Date:  2004-12-22       Impact factor: 17.970

Review 4.  Understanding alternative splicing: towards a cellular code.

Authors:  Arianne J Matlin; Francis Clark; Christopher W J Smith
Journal:  Nat Rev Mol Cell Biol       Date:  2005-05       Impact factor: 94.444

5.  The human SWI/SNF subunit Brm is a regulator of alternative splicing.

Authors:  Eric Batsché; Moshe Yaniv; Christian Muchardt
Journal:  Nat Struct Mol Biol       Date:  2005-12-11       Impact factor: 15.369

6.  RNAi-mediated PTB depletion leads to enhanced exon definition.

Authors:  Eric J Wagner; Mariano A Garcia-Blanco
Journal:  Mol Cell       Date:  2002-10       Impact factor: 17.970

7.  An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein.

Authors:  R P Carstens; E J Wagner; M A Garcia-Blanco
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

8.  Transcriptional activators differ in their abilities to control alternative splicing.

Authors:  Guadalupe Nogues; Sebastian Kadener; Paula Cramer; David Bentley; Alberto R Kornblihtt
Journal:  J Biol Chem       Date:  2002-09-06       Impact factor: 5.157

9.  Biased chromatin signatures around polyadenylation sites and exons.

Authors:  Noah Spies; Cydney B Nielsen; Richard A Padgett; Christopher B Burge
Journal:  Mol Cell       Date:  2009-10-23       Impact factor: 17.970

10.  MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb.

Authors:  Nicole D Robson-Dixon; Mariano A Garcia-Blanco
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157
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  512 in total

Review 1.  Next-generation genomics: an integrative approach.

Authors:  R David Hawkins; Gary C Hon; Bing Ren
Journal:  Nat Rev Genet       Date:  2010-07       Impact factor: 53.242

2.  Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.

Authors:  Humaira Gowher; Kevin Brick; R Daniel Camerini-Otero; Gary Felsenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

3.  CTCF: from insulators to alternative splicing regulation.

Authors:  Alberto R Kornblihtt
Journal:  Cell Res       Date:  2012-02-07       Impact factor: 25.617

4.  Mediator complex regulates alternative mRNA processing via the MED23 subunit.

Authors:  Yan Huang; Wencheng Li; Xiao Yao; Qi-Jiang Lin; Jing-Wen Yin; Yan Liang; Monika Heiner; Bin Tian; Jingyi Hui; Gang Wang
Journal:  Mol Cell       Date:  2012-01-19       Impact factor: 17.970

Review 5.  More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.

Authors:  Anupam K Chakravarty; Daniel F Jarosz
Journal:  J Mol Biol       Date:  2018-07-19       Impact factor: 5.469

6.  Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer.

Authors:  Isaac K Sundar; Michael Z Nevid; Alan E Friedman; Irfan Rahman
Journal:  J Proteome Res       Date:  2013-12-13       Impact factor: 4.466

Review 7.  The rise of regulatory RNA.

Authors:  Kevin V Morris; John S Mattick
Journal:  Nat Rev Genet       Date:  2014-04-29       Impact factor: 53.242

8.  Genome-Wide Analysis of Heat-Sensitive Alternative Splicing in Physcomitrella patens.

Authors:  Chiung-Yun Chang; Wen-Dar Lin; Shih-Long Tu
Journal:  Plant Physiol       Date:  2014-04-28       Impact factor: 8.340

9.  Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1.

Authors:  Kenneth J Dery; Craig Silver; Lu Yang; John E Shively
Journal:  J Biol Chem       Date:  2018-05-02       Impact factor: 5.157

Review 10.  Co-Transcriptional RNA Processing in Plants: Exploring from the Perspective of Polyadenylation.

Authors:  Jing Yang; Ying Cao; Ligeng Ma
Journal:  Int J Mol Sci       Date:  2021-03-24       Impact factor: 5.923
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