| Literature DB >> 20129796 |
Cahide Gokkusu1, Feti Tulubas, Yesim Unlucerci, Elif Ozkok, Berrin Umman, Makbule Aydin.
Abstract
Inflammation is involved in development and progression of atherosclerosis. Interleukin-2 (IL-2) and interleukin-6 (IL-6) have been correlated with various cardiovascular diseases. Hyperhomocysteinemia is an important risk factor for atherosclerosis and thrombotic disease. Recent studies have demonstrated that homocysteine (Hcy) enhances productions of several pro-inflammatory cytokines. In the light of these findings, we decided to determine if any relationship exists between IL-2 and IL-6, the pro-inflammatory cytokines, and total homocysteine (tHcy) in acute coronary syndrome (ACS). A total of 102 patients with ACS and 90 healthy subjects were included in the study. The levels of tHcy, IL-2 and IL-6 were higher and folic acid was lower in patients as compared with those of controls. Furthermore, data of the area under ROC plot for IL-2 demonstrated that IL-2 had higher sensitivity. These data suggest that enhanced inflammation may be associated with tHcy-related cardiovascular disease. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20129796 DOI： 10.1016/j.cyto.2009.12.015
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861