Literature DB >> 2012975

Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment.

M W Robertson1, C A Leslie, J P Bennett.   

Abstract

The effects on motor behavior and forebrain dopamine (DA) synaptic function of withdrawal from chronic cocaine treatment were examined with simultaneous activity monitoring and microdialysis in nucleus accumbens. Rats exhibited behavioral sensitization to daily 30 mg/kg i.p. cocaine. After 18 days of daily cocaine and 7 days of withdrawal, dialysate DA and homovanillic acid (HVA) levels were reduced 36-38%, consistent with a synaptic DA deficiency.

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Year:  1991        PMID： 2012975     DOI： 10.1016/0006-8993(91)90451-z

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  26 in total

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