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Literature DB >> 20127889

How the epigenome contributes to the development of psychiatric disorders.

Timothy W Bredy¹, Yi E Sun, Michael S Kobor.

Abstract

Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the "epigenome" represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Histones

Year: 2010 PMID： 20127889 PMCID： PMC2946415 DOI： 10.1002/dev.20424

Source DB: PubMed Journal: Dev Psychobiol ISSN： 0012-1630 Impact factor: 3.038

137 in total

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19 in total

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