| Literature DB >> 20122882 |
Abstract
The FANCJ protein (also known as BACH1 and BRIP1) is a DNA helicase that is required to preserve the genetic and structural integrity of the genome in complex eukaryotes. In humans, mutations in FANCJ are associated with the chromosome instability disorder Fanconi's anemia and also with the inherited predisposition early-onset breast cancer. Here I will discuss the contribution of FANCJ to human disease, its role in maintenance of genome stability and some current thoughts on the mechanisms through which this is achieved. (c) 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20122882 DOI： 10.1016/j.dnarep.2010.01.005
Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856