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Literature DB >> 20118565

Role of the SDF-1/CXCR4 system in myocardial infarction.

Abstract

Myocardial infarction (MI) is accompanied by an inflammatory response, leading to the recruitment of leukocytes and subsequent myocardial injury and healing. Chemokines are potent chemoattractant cytokines that regulate leukocyte trafficking in inflammatory processes. Recent evidence indicates that chemokines play a role not only in leukocyte trafficking but also in angiogenesis and cardioprotection. In particular, stromal cell-derived factor-1alpha (SDF-1alpha) has generated considerable interest for its role in the pathophysiology of MI. This review will focus on the role of SDF-1 and its receptor CXC chemokine receptor 4 (CXCR4; ie, the SDF-1/CXCR4 system) in the pathophysiology of MI and discuss their potential as therapeutic targets for MI.

Entities: Disease Gene

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Year: 2010 PMID： 20118565 DOI： 10.1253/circj.cj-09-1021

Source DB: PubMed Journal: Circ J ISSN： 1346-9843 Impact factor: 2.993

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Cited

22 in total

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